OBJECTIVE: To study the association of blood groups with different types of glaucoma including primary open-angle glaucoma (POAG), primary closed-angle glaucoma (PCAG), and pseudoexfoliative glaucoma (PEXG) in the Pakistani population. STUDY DESIGN: The present study was a prospective case control study. PARTICIPANTS: ABO and Rh blood groups were analyzed in 2046 controls and 477 glaucoma patients (220 POAG, 146 PCAG, and 111 PEXG). METHODS: Hemagglutination patterns were used to determine the prevalence of the ABO and Rh blood groups in all the subjects. Logistic regression analysis was carried out to evaluate any association of the different blood groups with glaucoma. RESULTS: In the present study, the percentage of blood groups A, B, AB, and O in patients was found to be 19%, 41%, 10%, and 30%, and in the control group, the values were 26%, 31%, 12%, and 31%, respectively. A significant positive association was found between the B blood group and glaucoma (p value < 0.05, odds ratio [OR] 1.5, and c2 15.8). Logistic regression analysis revealed that the blood group B was associated with all types of glaucoma with OR of 1.35 (95% CI 1.01-1.80; p = 0.04) for POAG, 1.71 (95% CI 1.21-2.40; p = 0.002) for PCAG, and 1.61 (95% CI 1.09-2.36; p = 0.016) for PEXG. POAG was also found to be associated with the Rh- allele (p < 0.05) with an OR of 4.05 (95% CI 2.98-5.51), as compared with controls. CONCLUSIONS: In the Pakistani patient cohort, blood group B is associated with all types of glaucoma and the Rhallele is associated only with POAG.
OBJECTIVE: To study the association of blood groups with different types of glaucoma including primary open-angle glaucoma (POAG), primary closed-angle glaucoma (PCAG), and pseudoexfoliative glaucoma (PEXG) in the Pakistani population. STUDY DESIGN: The present study was a prospective case control study. PARTICIPANTS: ABO and Rh blood groups were analyzed in 2046 controls and 477 glaucomapatients (220 POAG, 146 PCAG, and 111 PEXG). METHODS: Hemagglutination patterns were used to determine the prevalence of the ABO and Rh blood groups in all the subjects. Logistic regression analysis was carried out to evaluate any association of the different blood groups with glaucoma. RESULTS: In the present study, the percentage of blood groups A, B, AB, and O in patients was found to be 19%, 41%, 10%, and 30%, and in the control group, the values were 26%, 31%, 12%, and 31%, respectively. A significant positive association was found between the B blood group and glaucoma (p value < 0.05, odds ratio [OR] 1.5, and c2 15.8). Logistic regression analysis revealed that the blood group B was associated with all types of glaucoma with OR of 1.35 (95% CI 1.01-1.80; p = 0.04) for POAG, 1.71 (95% CI 1.21-2.40; p = 0.002) for PCAG, and 1.61 (95% CI 1.09-2.36; p = 0.016) for PEXG. POAG was also found to be associated with the Rh- allele (p < 0.05) with an OR of 4.05 (95% CI 2.98-5.51), as compared with controls. CONCLUSIONS: In the Pakistani patient cohort, blood group B is associated with all types of glaucoma and the Rhallele is associated only with POAG.
Authors: Pirro G Hysi; Ching-Yu Cheng; Henriët Springelkamp; Stuart Macgregor; Jessica N Cooke Bailey; Robert Wojciechowski; Veronique Vitart; Abhishek Nag; Alex W Hewitt; René Höhn; Cristina Venturini; Alireza Mirshahi; Wishal D Ramdas; Gudmar Thorleifsson; Eranga Vithana; Chiea-Chuen Khor; Arni B Stefansson; Jiemin Liao; Jonathan L Haines; Najaf Amin; Ya Xing Wang; Philipp S Wild; Ayse B Ozel; Jun Z Li; Brian W Fleck; Tanja Zeller; Sandra E Staffieri; Yik-Ying Teo; Gabriel Cuellar-Partida; Xiaoyan Luo; R Rand Allingham; Julia E Richards; Andrea Senft; Lennart C Karssen; Yingfeng Zheng; Céline Bellenguez; Liang Xu; Adriana I Iglesias; James F Wilson; Jae H Kang; Elisabeth M van Leeuwen; Vesteinn Jonsson; Unnur Thorsteinsdottir; Dominiek D G Despriet; Sarah Ennis; Sayoko E Moroi; Nicholas G Martin; Nomdo M Jansonius; Seyhan Yazar; E-Shyong Tai; Philippe Amouyel; James Kirwan; Leonieke M E van Koolwijk; Michael A Hauser; Fridbert Jonasson; Paul Leo; Stephanie J Loomis; Rhys Fogarty; Fernando Rivadeneira; Lisa Kearns; Karl J Lackner; Paulus T V M de Jong; Claire L Simpson; Craig E Pennell; Ben A Oostra; André G Uitterlinden; Seang-Mei Saw; Andrew J Lotery; Joan E Bailey-Wilson; Albert Hofman; Johannes R Vingerling; Cécilia Maubaret; Norbert Pfeiffer; Roger C W Wolfs; Hans G Lemij; Terri L Young; Louis R Pasquale; Cécile Delcourt; Timothy D Spector; Caroline C W Klaver; Kerrin S Small; Kathryn P Burdon; Kari Stefansson; Tien-Yin Wong; Ananth Viswanathan; David A Mackey; Jamie E Craig; Janey L Wiggs; Cornelia M van Duijn; Christopher J Hammond; Tin Aung Journal: Nat Genet Date: 2014-08-31 Impact factor: 38.330