Literature DB >> 19786599

Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.

Marçal Mariné1, F Javier Pastor, Ismail H Sahand, José Pontón, Guillermo Quindós, Josep Guarro.   

Abstract

Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.

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Year:  2009        PMID： 19786599      PMCID： PMC2786325          DOI： 10.1128/AAC.00980-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Candida dubliniensis bloodstream infection: a fatal case in a lung transplant recipient.

Authors:  S Mubareka; D C Vinh; S E Sanche
Journal:  Transpl Infect Dis       Date:  2005 Sep-Dec       Impact factor: 2.228

2.  Candida albicans and Candida dubliniensis respond differently to echinocandin antifungal agents in vitro.

Authors:  Mette D Jacobsen; Julie A Whyte; Frank C Odds
Journal:  Antimicrob Agents Chemother       Date:  2007-02-16       Impact factor: 5.191

3.  Breakthrough Candida dubliniensis fungemia in an acute myeloid leukemia patient during voriconazole therapy successfully treated with caspofungin.

Authors:  R Fanci
Journal:  J Chemother       Date:  2009-02       Impact factor: 1.714

4.  Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata.

Authors:  Marçal Mariné; Carolina Serena; Belkys Fernández-Torres; F Javier Pastor; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

5.  Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).

Authors:  R Hajdu; R Thompson; J G Sundelof; B A Pelak; F A Bouffard; J F Dropinski; H Kropp
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

6.  Assessment of the paradoxical effect of caspofungin in therapy of candidiasis.

Authors:  Karl V Clemons; Marife Espiritu; Rachana Parmar; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

7.  Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States.

Authors:  Luis Ostrosky-Zeichner; John H Rex; Peter G Pappas; Richard J Hamill; Robert A Larsen; Harold W Horowitz; William G Powderly; Newton Hyslop; Carol A Kauffman; John Cleary; Julie E Mangino; Jeannette Lee
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

8.  In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model.

Authors:  D R Andes; D J Diekema; M A Pfaller; K Marchillo; J Bohrmueller
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

9.  Candida dubliniensis candidemia in Australia.

Authors:  D Marriott; M Laxton; J Harkness
Journal:  Emerg Infect Dis       Date:  2001 May-Jun       Impact factor: 6.883

10.  Candida dubliniensis meningitis as delayed sequela of treated C. dubliniensis fungemia.

Authors:  Sebastian J van Hal; Damien Stark; John Harkness; Deborah Marriott
Journal:  Emerg Infect Dis       Date:  2008-02       Impact factor: 6.883
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  10 in total

1.  Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum.

Authors:  Ryan K Shields; M Hong Nguyen; Chen Du; Ellen Press; Shaoji Cheng; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

2.  Usefulness of the Non-conventional Caenorhabditis elegans Model to Assess Candida Virulence.

Authors:  Marcelo Ortega-Riveros; Iker De-la-Pinta; Cristina Marcos-Arias; Guillermo Ezpeleta; Guillermo Quindós; Elena Eraso
Journal:  Mycopathologia       Date:  2017-05-18       Impact factor: 2.574

3.  In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.

Authors:  Sandra Gil-Alonso; Nerea Jauregizar; Emilia Cantón; Elena Eraso; Guillermo Quindós
Journal:  Antimicrob Agents Chemother       Date:  2015-03-23       Impact factor: 5.191

4.  Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species.

Authors:  Fernando C Bizerra; Analy S A Melo; Eduardo Katchburian; Edna Freymüller; Anita H Straus; Hélio K Takahashi; Arnaldo L Colombo
Journal:  Antimicrob Agents Chemother       Date:  2010-11-08       Impact factor: 5.191

5.  Deciphering Candida auris Paradoxical Growth Effect (Eagle Effect) in Response to Echinocandins.

Authors:  Milena Kordalewska; David S Perlin
Journal:  Methods Mol Biol       Date:  2022

6.  Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence.

Authors:  Cristina Rueda; Manuel Cuenca-Estrella; Oscar Zaragoza
Journal:  Antimicrob Agents Chemother       Date:  2013-12-02       Impact factor: 5.191

7.  Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris.

Authors:  Milena Kordalewska; Annie Lee; Steven Park; Indira Berrio; Anuradha Chowdhary; Yanan Zhao; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

8.  Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species.

Authors:  Jeffrey B Locke; Amanda L Almaguer; Douglas E Zuill; Ken Bartizal
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

9.  Minimal Inhibitory Concentration (MIC)-Phenomena in Candida albicans and Their Impact on the Diagnosis of Antifungal Resistance.

Authors:  Ulrike Binder; Maria Aigner; Brigitte Risslegger; Caroline Hörtnagl; Cornelia Lass-Flörl; Michaela Lackner
Journal:  J Fungi (Basel)       Date:  2019-09-04

Review 10.  Recent Insights into the Paradoxical Effect of Echinocandins.

Authors:  Johannes Wagener; Veronika Loiko
Journal:  J Fungi (Basel)       Date:  2017-12-28
  10 in total

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