OBJECTIVE: Oxidative stress is implicated in Parkinson's disease (PD) and Alzheimer's disease (AD), and heme oxygenase-1 (HO-1) is a potent antioxidant overexpressed in PD substantia nigra and AD cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. The role of HO-1 in peripheral blood of PD and AD patients remains unresolved. METHODS: We measured serum HO-1 levels in 107 patients with PD, 105 patients with AD, 104 controls for PD and 120 controls for AD. RESULTS: The median serum concentration of HO-1 was significantly higher in PD patients (2.04 ng/ml) compared with that of PD controls (1.69 ng/ml, P = 0.016), with PD patients predominating over controls in the upper tertile of serum HO-1 levels, whereas there was more PD controls than PD patients in the lower tertile (P = 0.006). Median serum levels of HO-1 did not differ significantly between AD patients and AD controls. CONCLUSION: The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain.
OBJECTIVE: Oxidative stress is implicated in Parkinson's disease (PD) and Alzheimer's disease (AD), and heme oxygenase-1 (HO-1) is a potent antioxidant overexpressed in PD substantia nigra and AD cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. The role of HO-1 in peripheral blood of PD and ADpatients remains unresolved. METHODS: We measured serum HO-1 levels in 107 patients with PD, 105 patients with AD, 104 controls for PD and 120 controls for AD. RESULTS: The median serum concentration of HO-1 was significantly higher in PDpatients (2.04 ng/ml) compared with that of PD controls (1.69 ng/ml, P = 0.016), with PDpatients predominating over controls in the upper tertile of serum HO-1 levels, whereas there was more PD controls than PDpatients in the lower tertile (P = 0.006). Median serum levels of HO-1 did not differ significantly between ADpatients and AD controls. CONCLUSION: The increase of serum HO-1 levels in PDpatients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain.
Authors: Alberto Delaidelli; Mette Richner; Lixiang Jiang; Amelia van der Laan; Ida Bergholdt Jul Christiansen; Nelson Ferreira; Jens R Nyengaard; Christian B Vægter; Poul H Jensen; Ian R Mackenzie; Poul H Sorensen; Asad Jan Journal: Acta Neuropathol Commun Date: 2021-06-06 Impact factor: 7.801