Literature DB >> 19785069

siRNA and miRNA for the treatment of cancer.

R Jankovic1, S Radulovic, M Brankovic-Magic.   

Abstract

In the process of RNA interference (RNAi), small RNAs pair with complementary messenger RNAs preventing their expression. The discovery of RNAi has revolutionized our understanding of gene regulation. Since cancer is a disease of altered genes, RNAi may have tremendous potential as a therapeutic strategy by downregulating altered genes. Just one decade after its discovery, this process is already being used in clinical trials and new technical achievements in delivering small RNAs to the cells are constantly improving the efficiency of this specific cancer treatment.

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Year:  2009        PMID： 19785069

Source DB:  PubMed          Journal:  J BUON        ISSN： 1107-0625            Impact factor:   2.533


  6 in total

1.  Regulation of growth of human bladder cancer by miR-192.

Authors:  Yongchao Jin; Jiasun Lu; Jiling Wen; Yinzhou Shen; Xiaofei Wen
Journal:  Tumour Biol       Date:  2015-01-09

2.  Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells.

Authors:  E Ji-Fu; Jun-Jie Xing; Li-Qiang Hao; Chuan-Gang Fu
Journal:  Mol Biol Rep       Date:  2011-07-06       Impact factor: 2.316

3.  Molecular regulation of ovarian cancer cell invasion.

Authors:  Ningxia Sun; Qing Zhang; Chen Xu; Qian Zhao; Yan Ma; Xinmei Lu; Liang Wang; Wen Li
Journal:  Tumour Biol       Date:  2014-08-15

4.  microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer.

Authors:  Aijun Yang; Xuenan Wang; Chunna Yu; Zhenzhen Jin; Lingxia Wei; Jinghe Cao; Qin Wang; Min Zhang; Lin Zhang; Lei Zhang; Cuifang Hao
Journal:  Oncol Lett       Date:  2017-06-30       Impact factor: 2.967

5.  Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.

Authors:  Natalya S Petrova; Ivan V Chernikov; Mariya I Meschaninova; Iiya S Dovydenko; Aliya G Venyaminova; Marina A Zenkova; Valentin V Vlassov; Elena L Chernolovskaya
Journal:  Nucleic Acids Res       Date:  2011-11-10       Impact factor: 16.971

6.  Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.

Authors:  Yunliang Xie; Yanbo Liu; Weigao Shen; Bo Zhang; Qun Liu
Journal:  Neural Regen Res       Date:  2012-05-05       Impact factor: 5.135
  6 in total

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