PURPOSE: To determine the involvement of ZIC2 in oral squamous cell carcinoma (OSCC). METHODS: ZIC2 mRNA and protein expression in primary OSCCs (n = 74), oral premalignant lesions (OPLs, n = 20) and five OSCC-derived cell lines (HSC-2, HSC-3, OK-92, H1, and Sa3) were analyzed by quantitative reverse transcriptase-polymerase chain reaction, Western blot and immunohistochemistry (IHC). In addition, we evaluated the correlation between ZIC2 IHC scores in OSCCs and the clinicopathologic status. RESULTS: Significant up-regulation of ZIC2 was detected in OSCC-derived cell lines (P < 0.05), primary OSCCs (P < 0.05) and OPLs (P < 0.05) compared with normal counterparts. Among the clinical variables analyzed, ZIC2 expression was associated with the histopathologic types of OSCC. Furthermore, the survival rates differed significantly between ZIC2-positive cases and ZIC2-negative cases. CONCLUSIONS: These results suggested that ZIC2 expression is correlated with the differentiation type of OSCC and diagnosis and might be a potential prognostic indicator and therapeutic target for OSCCs.
PURPOSE: To determine the involvement of ZIC2 in oral squamous cell carcinoma (OSCC). METHODS:ZIC2 mRNA and protein expression in primary OSCCs (n = 74), oral premalignant lesions (OPLs, n = 20) and five OSCC-derived cell lines (HSC-2, HSC-3, OK-92, H1, and Sa3) were analyzed by quantitative reverse transcriptase-polymerase chain reaction, Western blot and immunohistochemistry (IHC). In addition, we evaluated the correlation between ZIC2 IHC scores in OSCCs and the clinicopathologic status. RESULTS: Significant up-regulation of ZIC2 was detected in OSCC-derived cell lines (P < 0.05), primary OSCCs (P < 0.05) and OPLs (P < 0.05) compared with normal counterparts. Among the clinical variables analyzed, ZIC2 expression was associated with the histopathologic types of OSCC. Furthermore, the survival rates differed significantly between ZIC2-positive cases and ZIC2-negative cases. CONCLUSIONS: These results suggested that ZIC2 expression is correlated with the differentiation type of OSCC and diagnosis and might be a potential prognostic indicator and therapeutic target for OSCCs.
Authors: A O Güre; E Stockert; M J Scanlan; R S Keresztes; D Jäger; N K Altorki; L J Old; Y T Chen Journal: Proc Natl Acad Sci U S A Date: 2000-04-11 Impact factor: 11.205
Authors: Burcak Vural; Lin-Chi Chen; Pinar Saip; Yao-Tseng Chen; Zeki Ustuner; Mithat Gonen; Andrew J G Simpson; Lloyd J Old; Ugur Ozbek; Ali O Gure Journal: Cancer Date: 2005-06-15 Impact factor: 6.860
Authors: Sergio Marchini; Elizabeth Poynor; Richard R Barakat; Luca Clivio; Michela Cinquini; Robert Fruscio; Luca Porcu; Cecilia Bussani; Maurizio D'Incalci; Eugenio Erba; Michela Romano; Giorgio Cattoretti; Dionyssios Katsaros; Andrew Koff; Lucio Luzzatto Journal: Clin Cancer Res Date: 2012-06-25 Impact factor: 12.531