Literature DB >> 19784575

2-Hydroxydiplopterol, a new cytotoxic pentacyclic triterpenoid from the halotolerant fungus Aspergillus variecolor B-17.

Wen-Liang Wang1, Pei-Pei Liu, Ya-Peng Zhang, Jing Li, Hong-Wen Tao, Qian-Qun Gu, Wei-Ming Zhu.   

Abstract

A new hopane type pentacyclic triterpenoid, 2-hydroxydiplopterol (1) has been isolated from the metabolites produced by the halotolerant fungal strain Aspergillus variecolor B-17. The structure of 1 was determined by spectroscopic methods and single crystal X-Ray diffraction analysis. 2-Hydroxydiplopterol (1) exhibited cytotoxicity against K562 cells with an IC50 value of 22 microM.

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Year:  2009        PMID： 19784575     DOI： 10.1007/s12272-009-1904-8

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  3 in total

1.  Polyphasic taxonomy of Aspergillus section Aspergillus (formerly Eurotium), and its occurrence in indoor environments and food.

Authors:  A J Chen; V Hubka; J C Frisvad; C M Visagie; J Houbraken; M Meijer; J Varga; R Demirel; Ž Jurjević; A Kubátová; F Sklenář; Y G Zhou; R A Samson
Journal:  Stud Mycol       Date:  2017-07-12       Impact factor: 16.097

2.  Biosynthesis of Isoprene Units in Euphorbia lathyris Laticifers vs. Other Tissues: MVA and MEP Pathways, Compartmentation and Putative Endophytic Fungi Contribution.

Authors:  Clément Gastaldo; Agata Lipko; Estelle Motsch; Pierre Adam; Philippe Schaeffer; Michel Rohmer
Journal:  Molecules       Date:  2019-11-26       Impact factor: 4.411

3.  Ochraceopyronide, a Rare α-Pyrone-C-lyxofuranoside from a Soil-Derived Fungus Aspergillus ochraceopetaliformis.

Authors:  Mostafa A Asmaey; Dennis Abatis; Ahmed S Abdel-Razek; George Lambrinidis; Ioanna Chinou; Nikolas Fokialakis; Nikolaos Tsafantakis; Mohamed Shaaban; Nektarios Aligiannis
Journal:  Molecules       Date:  2021-06-29       Impact factor: 4.411
  3 in total

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