Literature DB >> 19783213

Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy.

Matthew L Broadhead1, Crispin R Dass, Peter F M Choong.   

Abstract

Pigment epithelium-derived factor (PEDF) has roles in antiangiogenesis and antitumourigenesis that are intimately entwined and is showing promise as a potential anticancer agent. However, the function of PEDF in the deregulated apoptotic pathways of malignant cells must first be fully characterized. Here, we review the currently known apoptotic pathways that are relevant to PEDF and cancer. Recently, a pathway that includes the PEDF receptor, PPARgamma and p53 has emerged. It is hoped that further characterization of this and other pathways involved in cancer will bring to light potential new therapeutic targets and approaches, which due to their specificity might be free of the morbidity associated with conventional chemotherapy.

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Year:  2009        PMID： 19783213     DOI： 10.1016/j.molmed.2009.08.003

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  19 in total

Review 1.  Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective.

Authors:  Katrina B Manalo; Peter F M Choong; S Patricia Becerra; Crispin R Dass
Journal:  Expert Opin Ther Pat       Date:  2011-01-05       Impact factor: 6.674

Review 2.  A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.

Authors:  D Engelmann; C Meier; V Alla; B M Pützer
Journal:  Oncogene       Date:  2014-11-10       Impact factor: 9.867

3.  Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs).

Authors:  Maria Demestre; Menderes Yusuf Terzi; Victor Mautner; Peter Vajkoczy; Andreas Kurtz; Ana Luisa Piña
Journal:  J Neurooncol       Date:  2013-12       Impact factor: 4.130

Review 4.  The yin and yang of VEGF and PEDF: multifaceted neurotrophic factors and their potential in the treatment of Parkinson's Disease.

Authors:  Torsten Falk; Robert T Gonzalez; Scott J Sherman
Journal:  Int J Mol Sci       Date:  2010-08-05       Impact factor: 5.923

5.  T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected].

Authors:  Daniel H Miller; Andrew K Fischer; Katrina F Chu; Risa Burr; Sara Hillenmeyer; Laurent Brard; Alexander S Brodsky
Journal:  Int J Gynecol Cancer       Date:  2011-11       Impact factor: 3.437

Review 6.  The role of exosomes in lung cancer metastasis and clinical applications: an updated review.

Authors:  Lei Yin; Xiaotian Liu; Xuejun Shao; Tao Feng; Jun Xu; Qi Wang; Shenghao Hua
Journal:  J Transl Med       Date:  2021-07-19       Impact factor: 5.531

7.  The molecular pathogenesis of osteosarcoma: a review.

Authors:  Matthew L Broadhead; Jonathan C M Clark; Damian E Myers; Crispin R Dass; Peter F M Choong
Journal:  Sarcoma       Date:  2011-04-13

8.  Proteome analysis of bronchoalveolar lavage in pulmonary langerhans cell histiocytosis.

Authors:  Claudia Landi; Elena Bargagli; Barbara Magi; Antje Prasse; Joachim Muller-Quernheim; Luca Bini; Paola Rottoli
Journal:  J Clin Bioinforma       Date:  2011-11-10

9.  Efficacy of continuously administered PEDF-derived synthetic peptides against osteosarcoma growth and metastasis.

Authors:  Matthew L Broadhead; Peter F M Choong; Crispin R Dass
Journal:  J Biomed Biotechnol       Date:  2012-05-30

Review 10.  Antimitotic drugs in the treatment of cancer.

Authors:  Rustelle Janse van Vuuren; Michelle H Visagie; Anne E Theron; Annie M Joubert
Journal:  Cancer Chemother Pharmacol       Date:  2015-11-12       Impact factor: 3.333
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