Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.

Literature DB >> 1978317

Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.

M G Blanton¹, J J Lo Turco, A R Kriegstein.

Abstract

Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1990 PMID： 1978317 PMCID： PMC54885 DOI： 10.1073/pnas.87.20.8027

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

33 in total

1. A series of stages in the embryonic development of Chelydra serpentina.

Authors: C L Yntema
Journal: J Morphol Date: 1968-06 Impact factor: 1.804

2. Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus.

Authors: N L Desmond; W B Levy
Journal: Brain Res Date: 1983-04-11 Impact factor: 3.252

3. Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice.

Authors: F L Chang; W T Greenough
Journal: Brain Res Date: 1984-08-20 Impact factor: 3.252

4. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5.

Authors: R G Morris; E Anderson; G S Lynch; M Baudry
Journal: Nature Date: 1986 Feb 27-Mar 5 Impact factor: 49.962

5. Magnesium gates glutamate-activated channels in mouse central neurones.

Authors: L Nowak; P Bregestovski; P Ascher; A Herbet; A Prochiantz
Journal: Nature Date: 1984 Feb 2-8 Impact factor: 49.962

6. The embryonic development of the cortical plate in reptiles: a comparative study in Emys orbicularis and Lacerta agilis.

Authors: A M Goffinet
Journal: J Comp Neurol Date: 1983-04-20 Impact factor: 3.215

7. Ion channels activated by L-glutamate and GABA in cultured cerebellar neurons of the rat.

Authors: S G Cull-Candy; D C Ogden
Journal: Proc R Soc Lond B Biol Sci Date: 1985-05-22

8. Structural substrates of epilepsy.

Authors: L A Paul; A B Scheibel
Journal: Adv Neurol Date: 1986

9. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.

Authors: G L Collingridge; S J Kehl; H McLennan
Journal: J Physiol Date: 1983-01 Impact factor: 5.182

9. Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation.

Authors: E R Bongarzone; S G Howard; V Schonmann; A T Campagnoni
Journal: J Neurosci Date: 1998-07-15 Impact factor: 6.167

10. Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo.

Authors: I Rajan; H T Cline
Journal: J Neurosci Date: 1998-10-01 Impact factor: 6.167

Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.

1. A series of stages in the embryonic development of Chelydra serpentina.

2. Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus.

3. Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice.

4. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5.

5. Magnesium gates glutamate-activated channels in mouse central neurones.

6. The embryonic development of the cortical plate in reptiles: a comparative study in Emys orbicularis and Lacerta agilis.

7. Ion channels activated by L-glutamate and GABA in cultured cerebellar neurons of the rat.

8. Structural substrates of epilepsy.

9. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.

10. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.

1. Enhanced NMDA receptor activity in retinal inputs to the rat suprachiasmatic nucleus during the subjective night.

2. Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death.

3. Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.

4. Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification.

Review 5. Electrical activity as a developmental regulator in the formation of spinal cord circuits.

6. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex.

7. Morphogenic potentials of D2, D3, and D4 dopamine receptors revealed in transfected neuronal cell lines.

8. Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture.

9. Identification of the dopamine D3 receptor in oligodendrocyte precursors: potential role in regulating differentiation and myelin formation.

10. Glutamate receptor activity is required for normal development of tectal cell dendrites in vivo.