| Literature DB >> 19782666 |
Yang Liu1, Yun-ming Li, Rui-feng Tian, Wei-ping Liu, Zhou Fei, Qian-fa Long, Xiao-an Wang, Xiang Zhang.
Abstract
HIF-1alpha plays an indispensable role in tumor formation and histogenesis. Target genes involved in glucose transport are acutely transactivated by HIF-1alpha. GLUT-3 protein is the rate-limiting factor related to glucose transport, which is classified as brain-type glucose transporter. This study was the initial one aiming to probe into the co-expression and clinical significance of HIF-1alpha and GLUT-3 in glioma. One hundred and twenty cases of glioma tissues and ten human normal cerebral tissues decompressed in glioma excision were examined using immunohistochemistry and Western blot. The expression of HIF-1alpha and GLUT-3 increased gradually with the increase of pathological grade of glioma, respectively. There was significant difference in the expression of HIF-1alpha and GLUT-3 in every two groups, respectively. There was a positive correlation between HIF-1alpha and GLUT-3. In conclusion, the expression of HIF-1alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma.Entities:
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Year: 2009 PMID： 19782666 DOI： 10.1016/j.brainres.2009.09.083
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252