| Literature DB >> 19782464 |
Xiaoxia Guo1, Bing Xu, Shuchita Pandey, Elisabeth Goessl, James Brown, Angel L Armesilla, John L Darling, Weiguang Wang.
Abstract
Most of the gemcitabine (dFdC) resistant cell lines manifested high NFkappaB activity. The NFkappaB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFkappaB inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2-1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced NFkappaB activity was markedly inhibited by DS/Cu complex. The data from this study indicated that DS may be used in clinic to improve the therapeutic effect of dFdC in breast and colon cancer patients. 2009. Published by Elsevier Ireland Ltd.Entities:
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Year: 2009 PMID： 19782464 DOI： 10.1016/j.canlet.2009.09.002
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679