BACKGROUND: Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present. METHODS: We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls. RESULTS: CSP length and prevalence of a large CSP did not differ between the groups, but bipolar patients had significantly shorter AI and larger third ventricles compared to controls. LIMITATIONS: A comprehensive investigation of medication effects was not possible due to incomplete medication data. CONCLUSIONS: These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder. Copyright (c) 2009 Elsevier B.V. All rights reserved.
BACKGROUND: Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present. METHODS: We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls. RESULTS: CSP length and prevalence of a large CSP did not differ between the groups, but bipolarpatients had significantly shorter AI and larger third ventricles compared to controls. LIMITATIONS: A comprehensive investigation of medication effects was not possible due to incomplete medication data. CONCLUSIONS: These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder. Copyright (c) 2009 Elsevier B.V. All rights reserved.
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