Literature DB >> 19782150

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs.

Sabine H van Rijt1, Peter J Sadler.   

Abstract

This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy.

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Year:  2009        PMID： 19782150      PMCID： PMC2933823          DOI： 10.1016/j.drudis.2009.09.003

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  64 in total

1.  Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway.

Authors:  Daniela Saggioro; Maria Pia Rigobello; Lucia Paloschi; Alessandra Folda; Stephen A Moggach; Simon Parsons; Luca Ronconi; Dolores Fregona; Alberto Bindoli
Journal:  Chem Biol       Date:  2007-10

2.  An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Authors:  Keiran S M Smalley; Rooha Contractor; Nikolas K Haass; Angela N Kulp; G Ekin Atilla-Gokcumen; Douglas S Williams; Howard Bregman; Keith T Flaherty; Maria S Soengas; Eric Meggers; Meenhard Herlyn
Journal:  Cancer Res       Date:  2007-01-01       Impact factor: 12.701

3.  Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions.

Authors:  Anna F A Peacock; Abraha Habtemariam; Rafael Fernández; Victoria Walland; Francesca P A Fabbiani; Simon Parsons; Rhona E Aird; Duncan I Jodrell; Peter J Sadler
Journal:  J Am Chem Soc       Date:  2006-02-08       Impact factor: 15.419

Review 4.  Metal based drugs: from serendipity to design.

Authors:  Simon Paul Fricker
Journal:  Dalton Trans       Date:  2007-09-19       Impact factor: 4.390

5.  Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.

Authors:  Haimei Chen; John A Parkinson; Olga Nováková; Juraj Bella; Fuyi Wang; Alice Dawson; Robert Gould; Simon Parsons; Viktor Brabec; Peter J Sadler
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

6.  A potent cytotoxic photoactivated platinum complex.

Authors:  Fiona S Mackay; Julie A Woods; Pavla Heringová; Jana Kaspárková; Ana M Pizarro; Stephen A Moggach; Simon Parsons; Viktor Brabec; Peter J Sadler
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-19       Impact factor: 11.205

7.  DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media.

Authors:  Hana Kostrhunova; Jakub Florian; Olga Novakova; Anna F A Peacock; Peter J Sadler; Viktor Brabec
Journal:  J Med Chem       Date:  2008-06-26       Impact factor: 7.446

8.  Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms.

Authors:  Haimei Chen; John A Parkinson; Robert E Morris; Peter J Sadler
Journal:  J Am Chem Soc       Date:  2003-01-08       Impact factor: 15.419

Review 9.  Thioredoxin signaling as a target for cancer therapy.

Authors:  Garth Powis; D Lynn Kirkpatrick
Journal:  Curr Opin Pharmacol       Date:  2007-07-03       Impact factor: 5.547

Review 10.  The resurgence of platinum-based cancer chemotherapy.

Authors:  Lloyd Kelland
Journal:  Nat Rev Cancer       Date:  2007-07-12       Impact factor: 60.716
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  56 in total

1.  New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.

Authors:  Bruno Demoro; Cynthia Sarniguet; Roberto Sánchez-Delgado; Miriam Rossi; Daniel Liebowitz; Francesco Caruso; Claudio Olea-Azar; Virtudes Moreno; Andrea Medeiros; Marcelo A Comini; Lucía Otero; Dinorah Gambino
Journal:  Dalton Trans       Date:  2011-12-02       Impact factor: 4.390

2.  Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents.

Authors:  Isabel de la Cueva-Alique; Laura Muñoz-Moreno; Yosra Benabdelouahab; Benelita T Elie; Mohammed Amin El Amrani; Marta E G Mosquera; María Contel; Ana M Bajo; Tomás Cuenca; Eva Royo
Journal:  J Inorg Biochem       Date:  2015-12-09       Impact factor: 4.155

3.  Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands.

Authors:  Sonja Ž Đurić; Sandra Vojnovic; Tina P Andrejević; Nevena Lj Stevanović; Nada D Savić; Jasmina Nikodinovic-Runic; Biljana Đ Glišić; Miloš I Djuran
Journal:  Bioinorg Chem Appl       Date:  2020-04-14       Impact factor: 7.778

4.  Metal-containing and related polymers for biomedical applications.

Authors:  Yi Yan; Jiuyang Zhang; Lixia Ren; Chuanbing Tang
Journal:  Chem Soc Rev       Date:  2016-02-24       Impact factor: 54.564

5.  The interactions of the ruthenium(II)-cymene complexes with lysozyme and cytochrome c.

Authors:  Dragana Stanic-Vucinic; Stefan Nikolic; Katarina Vlajic; Mirjana Radomirovic; Jelena Mihailovic; Tanja Cirkovic Velickovic; Sanja Grguric-Sipka
Journal:  J Biol Inorg Chem       Date:  2020-02-04       Impact factor: 3.358

6.  Competitive DNA-Binding Studies between Metal Complexes and GelRed as a New and Safe Fluorescent DNA Dye.

Authors:  Marzieh Anjomshoa; Masoud Torkzadeh-Mahani
Journal:  J Fluoresc       Date:  2016-06-20       Impact factor: 2.217

7.  Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways.

Authors:  Kogularamanan Suntharalingam; Timothy C Johnstone; Peter M Bruno; Wei Lin; Michael T Hemann; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2013-09-16       Impact factor: 15.419

8.  Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand as Potential Anticancer Agents.

Authors:  Monica Carreira; Rubén Calvo-Sanjuán; Mercedes Sanaú; Isabel Marzo; María Contel
Journal:  Organometallics       Date:  2012-07-25       Impact factor: 3.876

9.  Structurally diverse metal coordination compounds, bearing imidodiphosphinate and diphosphinoamine ligands, as potential inhibitors of the platelet activating factor.

Authors:  Alexandros B Tsoupras; Maria Roulia; Eleftherios Ferentinos; Ioannis Stamatopoulos; Constantinos A Demopoulos; Panayotis Kyritsis
Journal:  Bioinorg Chem Appl       Date:  2010-06-28       Impact factor: 7.778

10.  Melting thermodynamics of reversible DNA/ligand complexes at interfaces.

Authors:  Irina Belozerova; Rastislav Levicky
Journal:  J Am Chem Soc       Date:  2012-10-30       Impact factor: 15.419
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