| Literature DB >> 19782076 |
Xiang Li1, Ruth MacLeod, Allan J Dunlop, Helen V Edwards, Noopur Advant, Lucien C D Gibson, Nicola M Devine, Kim M Brown, David R Adams, Miles D Houslay, George S Baillie.
Abstract
Beta arrestins are molecular scaffolds that can bring together three-component mitogen-activated protein kinase signalling modules to promote signal compartmentalisation. We use peptide array technology to define novel interfaces between components within the c-Jun N-terminal kinase (JNK)/beta arrestin signalling complex. We show that beta arrestin 1 and beta arrestin 2 associate with JNK3 via the kinase N-terminal domain in a region that, surprisingly, does not harbour a known 'common docking' motif. In the N-domain and C-terminus of beta arrestin 1 and beta arrestin 2 we identify two novel apoptosis signal-regulating kinase 1 binding sites and in the N-domain of the beta arrestin 1 and beta arrestin 2 we identify a novel MKK4 docking site.Entities:
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Year: 2009 PMID： 19782076 DOI： 10.1016/j.febslet.2009.09.035
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124