Literature DB >> 19782022

Destruction of RhoA CULtivates actin.

Shuangding Wu1, Dieter A Wolf.   

Abstract

Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.

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Year:  2009        PMID： 19782022      PMCID： PMC3981991          DOI： 10.1016/j.molcel.2009.09.012

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Authors:  Stephen Orlicky; Xiaojing Tang; Andrew Willems; Mike Tyers; Frank Sicheri
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

Review 2.  Rho GTPases: biochemistry and biology.

Authors:  Aron B Jaffe; Alan Hall
Journal:  Annu Rev Cell Dev Biol       Date:  2005       Impact factor: 13.827

Review 3.  Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.

Authors:  Makoto Kobayashi; Masayuki Yamamoto
Journal:  Antioxid Redox Signal       Date:  2005 Mar-Apr       Impact factor: 8.401

4.  Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Authors:  Xiaojing Tang; Stephen Orlicky; Zhenyuan Lin; Andrew Willems; Dante Neculai; Derek Ceccarelli; Frank Mercurio; Brian H Shilton; Frank Sicheri; Mike Tyers
Journal:  Cell       Date:  2007-06-15       Impact factor: 41.582

5.  Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

Authors:  J D Singer; M Gurian-West; B Clurman; J M Roberts
Journal:  Genes Dev       Date:  1999-09-15       Impact factor: 11.361

6.  Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy.

Authors:  Martin Loignon; Weimin Miao; Lianggao Hu; Andrew Bier; Tarek A Bismar; P James Scrivens; Koren Mann; Mark Basik; Amélie Bouchard; Pierre O Fiset; Zachary Batist; Gerald Batist
Journal:  Mol Cancer Ther       Date:  2009-07-28       Impact factor: 6.261

7.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

8.  BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases.

Authors:  Rory Geyer; Susan Wee; Scott Anderson; John Yates; Dieter A Wolf
Journal:  Mol Cell       Date:  2003-09       Impact factor: 17.970

9.  A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.

Authors:  Izabela Sumara; Manfredo Quadroni; Claudia Frei; Michael H Olma; Grzegorz Sumara; Romeo Ricci; Matthias Peter
Journal:  Dev Cell       Date:  2007-06       Impact factor: 12.270

10.  Sequence and structural analysis of BTB domain proteins.

Authors:  Peter J Stogios; Gregory S Downs; Jimmy J S Jauhal; Sukhjeen K Nandra; Gilbert G Privé
Journal:  Genome Biol       Date:  2005-09-15       Impact factor: 13.583
  10 in total
  4 in total

1.  Ubiquitination: Added complexity in Ras and Rho family GTPase function.

Authors:  Michelle de la Vega; James F Burrows; James A Johnston
Journal:  Small GTPases       Date:  2011-07-01

2.  A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.

Authors:  Daisuke Hoshino; Naohiko Koshikawa; Motoharu Seiki
Journal:  J Biol Chem       Date:  2010-11-17       Impact factor: 5.157

Review 3.  Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.

Authors:  Wolfgang Dubiel; Dawadschargal Dubiel; Dieter A Wolf; Michael Naumann
Journal:  Trends Biochem Sci       Date:  2017-12-14       Impact factor: 13.807

4.  Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors.

Authors:  Kathy L McGraw; Ashley A Basiorka; Joseph O Johnson; Justine Clark; Gisela Caceres; Eric Padron; Ruth Heaton; Yukiyasu Ozawa; Sheng Wei; Lubomir Sokol; Alan F List
Journal:  PLoS One       Date:  2014-12-03       Impact factor: 3.240
  4 in total

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