Wahida Borgi1, Nabil Chouchane. 1. Laboratory of Pharmacology, Faculty of Pharmacy, Monastir 5000, Tunisia. wahida_b2002@yahoo.fr
Abstract
AIM OF THE STUDY: The present study deals with the anti-spasmodic activity of the aqueous and the methanolic extracts of the leaves and the root barks of Zizyphus lotus (L.) Desf. on male rats. MATERIALS AND METHODS: This activity was assessed on contractions of isolated rat duodenum, induced by acetylcholine, KCl, and BaCl(2) and compared with the effect of atropine and papaverine. RESULTS: Both extracts of leaves and root barks caused significant relaxation of spontaneous contractions and produced a concentration-dependent inhibition (P<0.01-0.001) of contraction induced by spasmogenic agents. CONCLUSION: These results indicate that Zizyphus lotus extracts contain anti-spasmodic constituents mediating their effect through cholinergic receptors and blockade Ca(2+) influx. This could explain the traditional use of Zizyphus lotus in the treatment of the intestinal diseases.
AIM OF THE STUDY: The present study deals with the anti-spasmodic activity of the aqueous and the methanolic extracts of the leaves and the root barks of Zizyphus lotus (L.) Desf. on male rats. MATERIALS AND METHODS: This activity was assessed on contractions of isolated rat duodenum, induced by acetylcholine, KCl, and BaCl(2) and compared with the effect of atropine and papaverine. RESULTS: Both extracts of leaves and root barks caused significant relaxation of spontaneous contractions and produced a concentration-dependent inhibition (P<0.01-0.001) of contraction induced by spasmogenic agents. CONCLUSION: These results indicate that Zizyphus lotus extracts contain anti-spasmodic constituents mediating their effect through cholinergic receptors and blockade Ca(2+) influx. This could explain the traditional use of Zizyphus lotus in the treatment of the intestinal diseases.
Authors: Sofia Zazouli; Mohammed Chigr; Patrícia A B Ramos; Daniela Rosa; Maria M Castro; Ahmed Jouaiti; Maria F Duarte; Sónia A O Santos; Armando J D Silvestre Journal: Molecules Date: 2022-01-13 Impact factor: 4.411