BACKGROUND:Aortic valve calcification (AVC) is associated with cardiovascular risk factors and coronary artery calcification. We sought to determine whether AVC is associated with the presence and extent of overall plaque burden, as well as to plaque composition (calcified, mixed, and noncalcified). METHODS: We examined 357 subjects (mean age 53 +/- 12 years, 61% male) who underwent contrast-enhanced electrocardiogram-gated 64-slice multidetector computed tomography from the ROMICAT trial for the assessment of presence and extent of coronary plaque burden according to the 17-coronary segment model and presence of AVC. RESULTS:Patients with AVC (n = 37, 10%) were more likely than those without AVC (n = 320, 90%) to have coexisting presence of any coronary plaque (89% vs 46%, P < .001) and had a greater extent of coronary plaque burden (6.4 vs 1.8 segments, P < .001). Those with AVC had >3-fold increase odds of having any plaque (adjusted odds ratio [OR] 3.6, P = .047) and an increase of 2.5 segments of plaque (P < .001) as compared to those without AVC. When stratified by plaque composition, AVC was associated most with calcified plaque (OR 5.2, P = .004), then mixed plaque (OR 3.2, P = .02), but not with noncalcified plaque (P = .96). CONCLUSION: Aortic valve calcification is associated with the presence and greater extent of coronary artery plaque burden and may be part of the later stages of the atherosclerosis process, as its relation is strongest with calcified plaque, less with mixed plaque, and nonsignificant with noncalcified plaque. If AVC is present, consideration for aggressive medical therapy may be warranted.
RCT Entities:
BACKGROUND:Aortic valve calcification (AVC) is associated with cardiovascular risk factors and coronary artery calcification. We sought to determine whether AVC is associated with the presence and extent of overall plaque burden, as well as to plaque composition (calcified, mixed, and noncalcified). METHODS: We examined 357 subjects (mean age 53 +/- 12 years, 61% male) who underwent contrast-enhanced electrocardiogram-gated 64-slice multidetector computed tomography from the ROMICAT trial for the assessment of presence and extent of coronary plaque burden according to the 17-coronary segment model and presence of AVC. RESULTS:Patients with AVC (n = 37, 10%) were more likely than those without AVC (n = 320, 90%) to have coexisting presence of any coronary plaque (89% vs 46%, P < .001) and had a greater extent of coronary plaque burden (6.4 vs 1.8 segments, P < .001). Those with AVC had >3-fold increase odds of having any plaque (adjusted odds ratio [OR] 3.6, P = .047) and an increase of 2.5 segments of plaque (P < .001) as compared to those without AVC. When stratified by plaque composition, AVC was associated most with calcified plaque (OR 5.2, P = .004), then mixed plaque (OR 3.2, P = .02), but not with noncalcified plaque (P = .96). CONCLUSION:Aortic valve calcification is associated with the presence and greater extent of coronary artery plaque burden and may be part of the later stages of the atherosclerosis process, as its relation is strongest with calcified plaque, less with mixed plaque, and nonsignificant with noncalcified plaque. If AVC is present, consideration for aggressive medical therapy may be warranted.
Authors: Ronit Katz; Nathan D Wong; Richard Kronmal; Junichiro Takasu; David M Shavelle; Jeffrey L Probstfield; Alain G Bertoni; Matthew J Budoff; Kevin D O'Brien Journal: Circulation Date: 2006-04-24 Impact factor: 29.690
Authors: Ralf Koos; Andreas Horst Mahnken; Harald Peter Kühl; Georg Mühlenbruch; Vera Mevissen; Ludwig Stork; Richard Dronskowski; Georg Langebartels; Rüdiger Autschbach; Jan R Ortlepp Journal: Invest Radiol Date: 2006-05 Impact factor: 6.016
Authors: Gilbert L Raff; Aiden Abidov; Stephan Achenbach; Daniel S Berman; Lawrence M Boxt; Matthew J Budoff; Victor Cheng; Tony DeFrance; Jeffrey C Hellinger; Ronald P Karlsberg Journal: J Cardiovasc Comput Tomogr Date: 2009-01-29
Authors: David Messika-Zeitoun; Lawrence F Bielak; Patricia A Peyser; Patrick F Sheedy; Stephen T Turner; Vuyisile T Nkomo; Jerome F Breen; Joseph Maalouf; Christopher Scott; A Jamil Tajik; Maurice Enriquez-Sarano Journal: Arterioscler Thromb Vasc Biol Date: 2006-12-21 Impact factor: 8.311
Authors: Caroline S Fox; Chao-Yu Guo; Martin G Larson; Ramachandran S Vasan; Helen Parise; Christopher J O'Donnell; Ralph B D'Agostino; John F Keaney; Emelia J Benjamin Journal: Am J Cardiol Date: 2006-03-29 Impact factor: 2.778
Authors: G Sangiorgi; J A Rumberger; A Severson; W D Edwards; J Gregoire; L A Fitzpatrick; R S Schwartz Journal: J Am Coll Cardiol Date: 1998-01 Impact factor: 24.094
Authors: Fabian Bamberg; Nina Dannemann; Michael D Shapiro; Sujith K Seneviratne; Maros Ferencik; Javed Butler; Wolfgang Koenig; Khurram Nasir; Ricardo C Cury; Ahmed Tawakol; Stephan Achenbach; Thomas J Brady; Udo Hoffmann Journal: Arterioscler Thromb Vasc Biol Date: 2008-01-03 Impact factor: 8.311
Authors: Matthew A Allison; Philip Cheung; Michael H Criqui; Robert D Langer; C Michael Wright Journal: Circulation Date: 2006-02-06 Impact factor: 29.690