BACKGROUND AND PURPOSE: Autonomic dysfunction is common in Parkinson's disease (PD) and causes a great impact in health-related quality of life (HRQL) and functional status of patients. This study is the first independent validation of the Scales for Outcomes in PD-Autonomic (SCOPA-AUT). METHODS: In an observational, cross-sectional study (ELEP Study), 387 PD patients were assessed using, in addition to the SCOPA-AUT, the Hoehn and Yahr staging, SCOPA-Motor, SCOPA-Cognition, Cumulative Illness Rating Scale-Geriatrics, modified Parkinson Psychosis Rating Scale, Clinical Impression of Severity Index for PD, Hospital Anxiety and Depression Scale, SCOPA-Sleep, SCOPA-Psychosocial, pain and fatigue visual analogue scales, and EQ-5D. SCOPA-AUT acceptability, internal consistency, construct validity, and precision were explored. RESULTS: Data quality was satisfactory (97%). SCOPA-AUT total score did not show floor or ceiling effect, and skewness was 0.40. Cronbach's alpha coefficients ranged from 0.64 (Cardiovascular and Thermorregulatory subscales) to 0.95 (Sexual dysfunction, women). Item homogeneity index was low (0.24) for Gastrointestinal subscale. Factor analysis identified eight factors for men (68% of the variance) and seven factors for women (65% of the variance). SCOPA-AUT correlated at a high level with specific HRQL and functional measures (r(S) = 0.52-0.56). SCOPA-AUT scores were higher for older patients, for more advanced disease, and for patients treated only with levodopa (Kruskal-Wallis test, P < 0.01). Standard error of measurement for SCOPA-AUT subscales was 0.81 (sexual, men) - 2.26 (gastrointestinal). CONCLUSIONS: Despite its heterogeneous content, which determines some weaknesses in the psychometric attributes of its subscales, SCOPA-AUT is an acceptable, consistent, valid and precise scale.
BACKGROUND AND PURPOSE:Autonomic dysfunction is common in Parkinson's disease (PD) and causes a great impact in health-related quality of life (HRQL) and functional status of patients. This study is the first independent validation of the Scales for Outcomes in PD-Autonomic (SCOPA-AUT). METHODS: In an observational, cross-sectional study (ELEP Study), 387 PDpatients were assessed using, in addition to the SCOPA-AUT, the Hoehn and Yahr staging, SCOPA-Motor, SCOPA-Cognition, Cumulative Illness Rating Scale-Geriatrics, modified Parkinson Psychosis Rating Scale, Clinical Impression of Severity Index for PD, Hospital Anxiety and Depression Scale, SCOPA-Sleep, SCOPA-Psychosocial, pain and fatigue visual analogue scales, and EQ-5D. SCOPA-AUT acceptability, internal consistency, construct validity, and precision were explored. RESULTS: Data quality was satisfactory (97%). SCOPA-AUT total score did not show floor or ceiling effect, and skewness was 0.40. Cronbach's alpha coefficients ranged from 0.64 (Cardiovascular and Thermorregulatory subscales) to 0.95 (Sexual dysfunction, women). Item homogeneity index was low (0.24) for Gastrointestinal subscale. Factor analysis identified eight factors for men (68% of the variance) and seven factors for women (65% of the variance). SCOPA-AUT correlated at a high level with specific HRQL and functional measures (r(S) = 0.52-0.56). SCOPA-AUT scores were higher for older patients, for more advanced disease, and for patients treated only with levodopa (Kruskal-Wallis test, P < 0.01). Standard error of measurement for SCOPA-AUT subscales was 0.81 (sexual, men) - 2.26 (gastrointestinal). CONCLUSIONS: Despite its heterogeneous content, which determines some weaknesses in the psychometric attributes of its subscales, SCOPA-AUT is an acceptable, consistent, valid and precise scale.
Authors: Anne Damian; Charles H Adler; Joseph G Hentz; Holly A Shill; John N Caviness; Marwan N Sabbagh; Virgilio G H Evidente; Thomas G Beach; Erika Driver-Dunckley Journal: Parkinsonism Relat Disord Date: 2012-07-06 Impact factor: 4.891
Authors: Amy W Amara; Lama M Chahine; Chelsea Caspell-Garcia; Jeffrey D Long; Christopher Coffey; Birgit Högl; Aleksandar Videnovic; Alex Iranzo; Geert Mayer; Nancy Foldvary-Schaefer; Ron Postuma; Wolfgang Oertel; Shirley Lasch; Ken Marek; Tanya Simuni Journal: J Neurol Neurosurg Psychiatry Date: 2017-05-29 Impact factor: 10.154
Authors: Tanya Simuni; Chelsea Caspell-Garcia; Christopher Coffey; Lama M Chahine; Shirley Lasch; Wolfgang H Oertel; Geert Mayer; Birgit Högl; Ron Postuma; Aleksandar Videnovic; Amy Willis Amara; Ken Marek Journal: Mov Disord Date: 2015-06-11 Impact factor: 10.338
Authors: S Bostantjopoulou; Z Katsarou; I Danglis; H Karakasis; D Milioni; C Falup-Pecurariu Journal: Hippokratia Date: 2016 Apr-Jun Impact factor: 0.471
Authors: Anne Pavy-Le Traon; Nikki Cotterill; Gerard Amarenco; Susanne Duerr; Horacio Kaufmann; Heinz Lahrmann; François Tison; Gregor K Wenning; Christopher G Goetz; Werner Poewe; Cristina Sampaio; Anette Schrag; Olivier Rascol; Pablo Martinez-Martin; Glenn T Stebbins Journal: Mov Disord Clin Pract Date: 2018-10-25