Literature DB >> 19780590

Cytotoxic diterpenoids from Croton argyrophylloides.

Hélcio S Santos1, Francisco W A Barros, Maria Rose Jane R Albuquerque, Paulo N Bandeira, Claúdia Pessoa, Raimundo Braz-Filho, Francisco J Q Monte, Jose Henrique Leal-Cardoso, Telma L G Lemos.   

Abstract

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.

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Year:  2009        PMID： 19780590     DOI： 10.1021/np900250k

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.

Authors:  E M Kithsiri Wijeratne; Bharat P Bashyal; Manping X Liu; Danilo D Rocha; G M Kamal B Gunaherath; Jana M U'Ren; Malkanthi K Gunatilaka; A Elizabeth Arnold; Luke Whitesell; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2012-01-20       Impact factor: 4.050

2.  Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.

Authors:  Shuangli Qiu; Xin Wu; Hongbo Liao; Xiaobin Zeng; Senwang Zhang; Xiaofen Lu; Xiaohong He; Xiaoqi Zhang; Wencai Ye; Hua Wu; Xiaohui Zhu
Journal:  Oncol Lett       Date:  2017-09-06       Impact factor: 2.967

Review 3.  Chemical Constituents from Croton Species and Their Biological Activities.

Authors:  Wen-Hui Xu; Wei-Yi Liu; Qian Liang
Journal:  Molecules       Date:  2018-09-12       Impact factor: 4.411

4.  Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections.

Authors:  Victor Alves Carneiro; Hélcio Silva Dos Santos; Francisco Vassiliepe Sousa Arruda; Paulo Nogueira Bandeira; Maria Rose Jane Ribeiro Albuquerque; Maria Olívia Pereira; Mariana Henriques; Benildo Sousa Cavada; Edson Holanda Teixeira
Journal:  Molecules       Date:  2010-12-30       Impact factor: 4.411
  4 in total

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