Literature DB >> 1978028

Type-specific antigens for serological discrimination of HTLV-I and HTLV-II infection.

Y M Chen1, T H Lee, S Z Wiktor, G M Shaw, E L Murphy, W A Blattner, M Essex.   

Abstract

55 HTLV-I (human T-cell lymphotropic virus) and 45 HTLV-II carriers, confirmed by HTLV-type specific polymerase chain reaction (PCR), were distinguished by western blot assays with recombinant HTLV I or II envelope glycoproteins. Recombinant protein (RP) B1 contains aminoacids 166-201 from HTLV-I exterior glycoprotein gp46 and was reactive with HTLV-I samples only. RP-IIB, which contains aminoacids 96-235 from HTLV-II exterior glycoprotein gp52, was reactive with all HTLV-II samples. 39 patients (86.6%) had high reactivity by densitometry. Of 55 HTLV-I samples, 35 (65.5%) had antibody reactivity to RP-IIB, but only 1 (1.8%) had high reactivity by densitometry. RP B1 and IIB western blot assays may replace the PCR test in diagnosis of HTLV infection.

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Year:  1990        PMID： 1978028     DOI： 10.1016/0140-6736(90)92769-e

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  6 in total

1.  Detection and differentiation of antibodies to human T-cell lymphotropic virus types I and II by the immunofluorescence method.

Authors:  D Gallo; L M Penning; C V Hanson
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

2.  Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

Authors:  P Horal; W W Hall; B Svennerholm; J Lycke; S Jeansson; L Rymo; M H Kaplan; A Vahlne
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

3.  Synthetic peptide-based immunoassays for distinguishing between human T-cell lymphotropic virus type I and type II infections in seropositive individuals.

Authors:  R B Lal; W Heneine; D L Rudolph; W B Present; D Hofhienz; T M Hartley; R F Khabbaz; J E Kaplan
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

4.  Isolation and characterization of simian T-cell leukemia virus type II from New World monkeys.

Authors:  Y M Chen; Y J Jang; P J Kanki; Q C Yu; J J Wang; R J Montali; K P Samuel; T S Papas
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103

5.  Discrimination between human T-cell lymphotropic virus type I and II (HTLV-I and HTLV-II) infections by using synthetic peptides representing an immunodominant region of the core protein (p19) of HTLV-I and HTLV-II.

Authors:  J Bonis; A Baillou; F Barin; M Verdier; B Janvier; F Denis
Journal:  J Clin Microbiol       Date:  1993-06       Impact factor: 5.948

6.  Effect of human T-cell lymphotrophic virus type 1 (HTLV-1) in seropositive infertile women on intracytoplasmic sperm injection (ICSI) outcome.

Authors:  Mahnaz Mansouri Torshizi; Amir Reza Khalighi; Mahla Fadavi Islam; Rahele Aram; Elham Sabouri; Hekmat Khalilifar; Hesam Roustaee
Journal:  Iran J Reprod Med       Date:  2014-01
  6 in total

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