OBJECTIVES: Age-related anatomical and morphologic vestibular deterioration has already been elaborated. Demonstrating a corresponding degradation in physiologic function, however, entails a much higher challenge. The objective of this study was to investigate age-related changes using rotational tests, caloric tests, and the vestibular-evoked myogenic potentials (VEMP) test. DESIGN: Eighty healthy human subjects (38 men and 42 women) ranging in age from 18 to 80 yrs participated in this study and were subjected to an extensive vestibular test battery. Function tests included sinusoidal harmonic acceleration tests, a pseudorandom rotation test, velocity step tests, a caloric test, and a VEMP test. RESULTS: No significant age trends were noted for the sinusoidal harmonic acceleration test and velocity step tests response parameters, in contrast to subtle decreasing gain values with advancing age for the pseudorandom rotation test. Increasing slow-component velocity values were measured with the caloric test, whereas the frequency parameter showed no relevant age changes. The largest age trends were detected with the VEMP, with decreasing amplitudes, increasing thresholds, and decreasing N1 latencies. All asymmetry parameters remained stable across the different age categories. CONCLUSIONS: Only subtle age changes could be demonstrated with the rotational and caloric tests, in contrast to more pronounced age trends with the VEMP.
OBJECTIVES: Age-related anatomical and morphologic vestibular deterioration has already been elaborated. Demonstrating a corresponding degradation in physiologic function, however, entails a much higher challenge. The objective of this study was to investigate age-related changes using rotational tests, caloric tests, and the vestibular-evoked myogenic potentials (VEMP) test. DESIGN: Eighty healthy human subjects (38 men and 42 women) ranging in age from 18 to 80 yrs participated in this study and were subjected to an extensive vestibular test battery. Function tests included sinusoidal harmonic acceleration tests, a pseudorandom rotation test, velocity step tests, a caloric test, and a VEMP test. RESULTS: No significant age trends were noted for the sinusoidal harmonic acceleration test and velocity step tests response parameters, in contrast to subtle decreasing gain values with advancing age for the pseudorandom rotation test. Increasing slow-component velocity values were measured with the caloric test, whereas the frequency parameter showed no relevant age changes. The largest age trends were detected with the VEMP, with decreasing amplitudes, increasing thresholds, and decreasing N1 latencies. All asymmetry parameters remained stable across the different age categories. CONCLUSIONS: Only subtle age changes could be demonstrated with the rotational and caloric tests, in contrast to more pronounced age trends with the VEMP.
Authors: Yuri Agrawal; Daniel M Merfeld; Fay B Horak; Mark S Redfern; Brad Manor; Kelly P Westlake; Gay R Holstein; Paul F Smith; Tanvi Bhatt; Nicolaas I Bohnen; Lewis A Lipsitz Journal: J Gerontol A Biol Sci Med Sci Date: 2020-11-13 Impact factor: 6.053
Authors: Yuri Agrawal; Raymond Van de Berg; Floris Wuyts; Leif Walther; Mans Magnusson; Esther Oh; Margaret Sharpe; Michael Strupp Journal: J Vestib Res Date: 2019 Impact factor: 2.354
Authors: Evi Verbecque; Floris L Wuyts; Robby Vanspauwen; Vincent Van Rompaey; Paul Van de Heyning; Luc Vereeck Journal: Eur Arch Otorhinolaryngol Date: 2020-08-05 Impact factor: 2.503
Authors: Amanda I Rodriguez; Elizabeth Marler; Denis Fitzpatrick; Thomas Creutz; Shauntelle A Cannon; Megan L A Thomas; Kristen L Janky Journal: Otol Neurotol Date: 2020-07 Impact factor: 2.619