PURPOSE OF REVIEW: Tubulointerstitial hypoxia in the kidney has been considered a hallmark of injury and mediator of disease progression. This review focuses on hypoxia-inducible factor (HIF)-1, a master transcription factor in cellular adaptation to hypoxia. RECENT FINDINGS: HIF-1alpha is expressed in the hypoxic tubular epithelium as well in as the papillary interstitium and glomerular epithelial cells. Although HIF-1 plays a protective role in a number of acute kidney injury models when overexpressed, its activation in chronic kidney disease results in multiple phenotypic changes, depending on the pathological context. SUMMARY: Hypoxia, especially HIF-1, is a critical mediator in the pathogenesis of chronic kidney disease. Underlying molecular mechanisms, together with responsible HIF target genes, are currently under investigation.
PURPOSE OF REVIEW: Tubulointerstitial hypoxia in the kidney has been considered a hallmark of injury and mediator of disease progression. This review focuses on hypoxia-inducible factor (HIF)-1, a master transcription factor in cellular adaptation to hypoxia. RECENT FINDINGS:HIF-1alpha is expressed in the hypoxic tubular epithelium as well in as the papillary interstitium and glomerular epithelial cells. Although HIF-1 plays a protective role in a number of acute kidney injury models when overexpressed, its activation in chronic kidney disease results in multiple phenotypic changes, depending on the pathological context. SUMMARY:Hypoxia, especially HIF-1, is a critical mediator in the pathogenesis of chronic kidney disease. Underlying molecular mechanisms, together with responsible HIF target genes, are currently under investigation.
Authors: Prabhleen Singh; Roland C Blantz; Christian Rosenberger; Francis B Gabbai; Trenton R Schoeb; Scott C Thomson Journal: J Am Soc Nephrol Date: 2012-01-19 Impact factor: 10.121
Authors: Alfonso Eirin; Xiang-Yang Zhu; Amrutesh S Puranik; Hui Tang; Kelly A McGurren; Andre J van Wijnen; Amir Lerman; Lilach O Lerman Journal: Kidney Int Date: 2017-02-24 Impact factor: 10.612