BACKGROUND: The frequency and grade of pulmonary complications after radiotherapy for breast cancer are still debated. This study evaluated changes in pulmonary function tests (PFTs) after radiotherapy in women with breast cancer. PATIENTS AND METHODS: Thirty-five consecutive eligible women with breast cancer underwent pulmonary function testing before and 3 months after adjuvant radiotherapy. Twenty-one of them also received chemotherapy. RESULTS: A significant decrease of forced vital capacity, forced expiratory volume in one second and carbon monoxide diffusing capacity was observed in the women treated with locoregional adjuvant radiotherapy and chemotherapy, whereas no decrease of the above parameters was evidenced in women treated exclusively with local adjuvant radiotherapy. CONCLUSION: Local adjuvant radiotherapy is not associated with any reduction in lung function parameters, however, locoregional adjuvant radiotherapy combined with chemotherapy shows a significant reduction in PFTs 3 months after radiotherapy completion.
BACKGROUND: The frequency and grade of pulmonary complications after radiotherapy for breast cancer are still debated. This study evaluated changes in pulmonary function tests (PFTs) after radiotherapy in women with breast cancer. PATIENTS AND METHODS: Thirty-five consecutive eligible women with breast cancer underwent pulmonary function testing before and 3 months after adjuvant radiotherapy. Twenty-one of them also received chemotherapy. RESULTS: A significant decrease of forced vital capacity, forced expiratory volume in one second and carbon monoxide diffusing capacity was observed in the women treated with locoregional adjuvant radiotherapy and chemotherapy, whereas no decrease of the above parameters was evidenced in women treated exclusively with local adjuvant radiotherapy. CONCLUSION: Local adjuvant radiotherapy is not associated with any reduction in lung function parameters, however, locoregional adjuvant radiotherapy combined with chemotherapy shows a significant reduction in PFTs 3 months after radiotherapy completion.
Authors: Jarrod T Bruce; Jerry M Tran; Gary Phillips; Pat Elder; John G Mastronarde; Steven M Devine; Craig C Hofmeister; Karen L Wood Journal: Clin Lymphoma Myeloma Leuk Date: 2012-09-15
Authors: Catherine M Sabiston; Carsten Wrosch; Angela J Fong; Jennifer Brunet; Patrick Gaudreau; Jennifer O'Loughlin; Sarkis Meterissian Journal: BMJ Open Date: 2018-07-28 Impact factor: 2.692
Authors: Katarzyna Domaszewska; Tomasz Pieńkowski; Arkadiusz Janiak; Dorota Bukowska; Maria Laurentowska Journal: Int J Environ Res Public Health Date: 2019-12-13 Impact factor: 3.390
Authors: Maria Jesus Vinolo-Gil; Rocío Martín-Valero; Francisco Javier Martín-Vega; Manuel Rodríguez-Huguet; Veronica Perez-Cabezas; Gloria Gonzalez-Medina Journal: Int J Environ Res Public Health Date: 2022-03-23 Impact factor: 3.390