Literature DB >> 19778848

Never say die: survival signaling in large granular lymphocyte leukemia.

Mithun Vinod Shah1, Ranran Zhang, Thomas P Loughran.   

Abstract

Large granular lymphocyte (LGL) leukemia is a rare disorder of mature cytotoxic T or natural killer cells. Large granular lymphocyte leukemia is characterized by the accumulation of cytotoxic cells in blood and infiltration in the bone marrow, liver, and spleen. Herein, we review clinical features of LGL leukemia. We focus our discussion on known survival signals believed to play a role in the pathogenesis of LGL leukemia and their potential therapeutic implications.

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Year:  2009        PMID： 19778848      PMCID： PMC4377229          DOI： 10.3816/CLM.2009.s.019

Source DB:  PubMed          Journal:  Clin Lymphoma Myeloma        ISSN： 1557-9190


  81 in total

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  5 in total

Review 1.  T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias.

Authors:  Rebecca J Watters; Xin Liu; Thomas P Loughran
Journal:  Leuk Lymphoma       Date:  2011-07-13

Review 2.  Immune aging and autoimmunity.

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3.  Large granular lymphocytic leukemia cured by allogeneic stem cell transplant: a case report.

Authors:  Edward Carey; Nicholas Ward; Maher Abdul-Hay
Journal:  J Med Case Rep       Date:  2022-06-08

Review 4.  Genomics of LGL leukemia and select other rare leukemia/lymphomas.

Authors:  Katharine B Moosic; Umadevi Paila; Kristine C Olson; Karolina Dziewulska; T Tiffany Wang; Jeffrey C Xing; Aakrosh Ratan; David J Feith; Thomas P Loughran; Thomas L Olson
Journal:  Best Pract Res Clin Haematol       Date:  2019-06-06       Impact factor: 3.020

5.  Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia.

Authors:  Assieh Saadatpour; Rui-Sheng Wang; Aijun Liao; Xin Liu; Thomas P Loughran; István Albert; Réka Albert
Journal:  PLoS Comput Biol       Date:  2011-11-10       Impact factor: 4.475
  5 in total

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