Literature DB >> 19778497

How DISC1 regulates postnatal brain development: girdin gets in on the AKT.

David Porteous1, Kirsty Millar.   

Abstract

In this issue of Neuron, Kim et al. and Enomoto et al. show that DISC1 plays a key role in regulating postnatal brain development though interaction with Girdin. Girdin in turn regulates AKT signaling. Thus, another facet of the role of DISC1 is established, shedding more light on fundamental brain processes and the developmental basis of major psychiatric disorders.

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Year:  2009        PMID： 19778497     DOI： 10.1016/j.neuron.2009.09.017

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  8 in total

1.  Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.

Authors:  Yun Wang; Naoko Kaneko; Naoya Asai; Atsushi Enomoto; Mayu Isotani-Sakakibara; Takuya Kato; Masato Asai; Yoshiki Murakumo; Haruko Ota; Takao Hikita; Takashi Namba; Keisuke Kuroda; Kozo Kaibuchi; Guo-li Ming; Hongjun Song; Kazunobu Sawamoto; Masahide Takahashi
Journal:  J Neurosci       Date:  2011-06-01       Impact factor: 6.167

Review 2.  DISC1 at 10: connecting psychiatric genetics and neuroscience.

Authors:  David J Porteous; J Kirsty Millar; Nicholas J Brandon; Akira Sawa
Journal:  Trends Mol Med       Date:  2011-10-19       Impact factor: 11.951

3.  Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.

Authors:  Yash Mittal; Yelena Pavlova; Mikel Garcia-Marcos; Pradipta Ghosh
Journal:  J Biol Chem       Date:  2011-07-28       Impact factor: 5.157

4.  DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness.

Authors:  Dinesh C Soares; Becky C Carlyle; Nicholas J Bradshaw; David J Porteous
Journal:  ACS Chem Neurosci       Date:  2011-08-05       Impact factor: 4.418

Review 5.  DISC1-binding proteins in neural development, signalling and schizophrenia.

Authors:  Nicholas J Bradshaw; David J Porteous
Journal:  Neuropharmacology       Date:  2010-12-31       Impact factor: 5.250

6.  MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del.

Authors:  Dejian Zhao; Mingyan Lin; Jian Chen; Erika Pedrosa; Anastasia Hrabovsky; H Matthew Fourcade; Deyou Zheng; Herbert M Lachman
Journal:  PLoS One       Date:  2015-07-14       Impact factor: 3.240

7.  Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

Authors:  Changsheng Lin; Jason Ear; Krishna Midde; Inmaculada Lopez-Sanchez; Nicolas Aznar; Mikel Garcia-Marcos; Irina Kufareva; Ruben Abagyan; Pradipta Ghosh
Journal:  Mol Biol Cell       Date:  2014-09-03       Impact factor: 4.138

Review 8.  Mutations in DISC1 alter IP3R and voltage-gated Ca2+ channel functioning, implications for major mental illness.

Authors:  Ann R Rittenhouse; Sonia Ortiz-Miranda; Agata Jurczyk
Journal:  Neuronal Signal       Date:  2021-12-07
  8 in total

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