Literature DB >> 19778306

Increased expression of human beta-defensin 3 in mollusca contagiosum.

U Meyer-Hoffert1, T Schwarz, J M Schröder, R Gläser.   

Abstract

The human beta defensins (hBDs)-2 and -3 are inducible antimicrobial peptides present in human skin. Besides an important role in fighting bacteria, they also have an antiviral function. Molluscum contagiosum (MC) is a cutaneous viral disease caused by the MC virus. Lesions show a tendency towards spontaneous regression, which might be caused by antiviral proteins such as defensins. We report a marked increase in hBD-3 immunoreactivity in MC lesions in contrast to hBD-2, which was only marginally increased. We suggest a role for the hBD-3 peptide in MC pathogenesis.

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Year:  2009        PMID： 19778306     DOI： 10.1111/j.1365-2230.2009.03640.x

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN： 0307-6938            Impact factor:   3.470


  7 in total

Review 1.  Current insights into the role of human β-defensins in atopic dermatitis.

Authors:  P Chieosilapatham; H Ogawa; F Niyonsaba
Journal:  Clin Exp Immunol       Date:  2017-08-04       Impact factor: 4.330

2.  Activity, expression and genetic variation of canine β-defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.

Authors:  Brian C Leonard; Stanley L Marks; Catherine A Outerbridge; Verena K Affolter; Anchasa Kananurak; Amy Young; Peter F Moore; Danika L Bannasch; Charles L Bevins
Journal:  J Innate Immun       Date:  2012-01-19       Impact factor: 7.349

3.  [The skin's own antibiotics. Important features of antimicrobial peptides for clinical practice].

Authors:  J Cordes; M Wittersheim; J Harder; R Gläser
Journal:  Hautarzt       Date:  2014-01       Impact factor: 0.751

Review 4.  Antimicrobial peptides: old molecules with new ideas.

Authors:  Teruaki Nakatsuji; Richard L Gallo
Journal:  J Invest Dermatol       Date:  2011-12-08       Impact factor: 8.551

Review 5.  The role of antimicrobial peptides in chronic inflammatory skin diseases.

Authors:  Małgorzata Marcinkiewicz; Sławomir Majewski
Journal:  Postepy Dermatol Alergol       Date:  2016-02-29       Impact factor: 1.837

Review 6.  Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis.

Authors:  Hai Le Thanh Nguyen; Juan Valentin Trujillo-Paez; Yoshie Umehara; Hainan Yue; Ge Peng; Chanisa Kiatsurayanon; Panjit Chieosilapatham; Pu Song; Ko Okumura; Hideoki Ogawa; Shigaku Ikeda; François Niyonsaba
Journal:  Int J Mol Sci       Date:  2020-10-14       Impact factor: 5.923

7.  Serum β-Defensin-2 Levels and Their Relationship with the Clinical Course and Prognosis in Patients with Crimean-Congo Hemorrhagic Fever.

Authors:  Osman Aksoy; Emine Parlak; Mehmet Parlak; Hülya Aksoy
Journal:  Med Princ Pract       Date:  2015-11-05       Impact factor: 1.927
  7 in total

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