| Literature DB >> 19778087 |
Hongbing Liu1, RuAngelie Edrada-Ebel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E G Müller, Victor Wray, Wenhan Lin, Peter Proksch.
Abstract
Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC(50) against L5178Y cell line: 0.6 microg/mL).Entities:
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Year: 2009 PMID： 19778087 DOI： 10.1021/np900220r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050