| Literature DB >> 19777997 |
Francis Gosselin1, Stephen Lau, Christian Nadeau, Thao Trinh, Paul D O'Shea, Ian W Davies.
Abstract
A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proximity-induced anionic cyclization, followed by imidazole synthesis and late-stage cyanation.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19777997 DOI： 10.1021/jo901798d
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354