| Literature DB >> 19777346 |
Araceli Díaz-Ruíz1, Camilo Ríos, Joselyn Carvajal-Sotelo, Alma Ortiz-Plata, Gerardo Pavel Espino-Solis, Marisela Méndez-Armenta, Sergio Montes, Antonio Monroy-Noyola.
Abstract
This study examined the neuroprotective ability of tetrapeptide L-Asp-Ala-His-Lys (DAHK) in permanent middle cerebral artery occlusion in rats. One DAHK dose (16 mg/kg) or saline solution were i.v. administered 30 min after occlusion and neurological deficit was evaluated at 2, 24, 48, 72 and 96 h using Longa scoring scale. The striatum infarction area was evaluated until 96 h after occlusion in both groups after staining with hematoxylin-eosin. DAHK-treated group showed a significant (P < 0.05) protection of 70% of neurological deficit at 96 h after occlusion, in comparison with the control-group that showed permanent neurological deficit. The DAHK-treated group showed a significant (P < 0.05) reduction of 52% infarction area in the striatum, as compared to control values. Results presented here support the possible therapeutic application of DAHK as a neuroprotective agent in human patients with stroke, as the peptide is part of human serum albumin, already being tested in clinical trials.Entities:
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Year: 2009 PMID： 19777346 DOI： 10.1007/s11064-009-0060-3
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996