Literature DB >> 19776550

Chromatin flow cytometry identifies changes in epigenetic cell states.

Nadine Obier1, Albrecht M Müller.   

Abstract

We report flow cytometric protocols that quantitatively display the levels of different histone modifications on the single cell level. This method allows the rapid and simultaneous analysis of the global levels of chromatin marks in combination with other flow cytometric features. We show that chromatin flow cytometry identifies changes in epigenetic marks, such as histone acetylation and methylation, in drug-treated and differentiated mouse embryonic stem cell populations. 2009 S. Karger AG, Basel.

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Year:  2009        PMID： 19776550     DOI： 10.1159/000240247

Source DB:  PubMed          Journal:  Cells Tissues Organs        ISSN： 1422-6405            Impact factor:   2.481


  5 in total

1.  Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.

Authors:  Sophia N Ononye; Michael D VanHeyst; E Zachary Oblak; Wangda Zhou; Mohamed Ammar; Amy C Anderson; Dennis L Wright
Journal:  ACS Med Chem Lett       Date:  2013-06-10       Impact factor: 4.345

2.  Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation.

Authors:  Nadine Obier; Qiong Lin; Pierre Cauchy; Vroni Hornich; Martin Zenke; Matthias Becker; Albrecht M Müller
Journal:  Stem Cell Rev Rep       Date:  2015-02       Impact factor: 5.739

Review 3.  Beyond the message: advantages of snapshot proteomics with single-cell mass cytometry in solid tumors.

Authors:  Akshitkumar M Mistry; Allison R Greenplate; Rebecca A Ihrie; Jonathan M Irish
Journal:  FEBS J       Date:  2019-01-07       Impact factor: 5.542

4.  PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.

Authors:  Linda Varagnolo; Qiong Lin; Nadine Obier; Christoph Plass; Johannes Dietl; Martin Zenke; Rainer Claus; Albrecht M Müller
Journal:  Sci Rep       Date:  2015-07-22       Impact factor: 4.379

5.  Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation.

Authors:  Timothy D Hewitson; Stephen G Holt; Sven-Jean Tan; Belinda Wigg; Chrishan S Samuel; Edward R Smith
Journal:  Front Pharmacol       Date:  2017-05-29       Impact factor: 5.810
  5 in total

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