Literature DB >> 1977615

Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom.

N I Kiyatkin1, I E Dulubova, I A Chekhovskaya, E V Grishin.   

Abstract

cDNA encoding the putative alpha-latrotoxin precursor was isolated from spider venom glands cDNA library and sequenced. The cDNA contained the 4203 base-pair open reading frame corresponding to the 156,855-Da protein composed of 1401 amino acids. Computer analysis of the deduced primary structure revealed the presence of various internal imperfect repeats mainly in its central and C-terminal regions.

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Year:  1990        PMID： 1977615     DOI： 10.1016/0014-5793(90)81250-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

1.  alpha-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane.

Authors:  M Khvotchev; T C Südhof
Journal:  EMBO J       Date:  2000-07-03       Impact factor: 11.598

2.  Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Authors:  V Kodoyianni; E M Maine; J Kimble
Journal:  Mol Biol Cell       Date:  1992-11       Impact factor: 4.138

3.  Neurotoxic acylpolyamines from spider venoms.

Authors:  K D McCormick; J Meinwald
Journal:  J Chem Ecol       Date:  1993-10       Impact factor: 2.626

4.  Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae.

Authors:  J Sidorova; L Breeden
Journal:  Mol Cell Biol       Date:  1993-02       Impact factor: 4.272

5.  Recruitment and diversification of an ecdysozoan family of neuropeptide hormones for black widow spider venom expression.

Authors:  Caryn McCowan; Jessica E Garb
Journal:  Gene       Date:  2013-12-05       Impact factor: 3.688

6.  alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.

Authors:  K Ichtchenko; M Khvotchev; N Kiyatkin; L Simpson; S Sugita; T C Südhof
Journal:  EMBO J       Date:  1998-11-02       Impact factor: 11.598

7.  Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones.

Authors:  G G Holz; J F Habener
Journal:  Comp Biochem Physiol B Biochem Mol Biol       Date:  1998-10       Impact factor: 2.231

8.  Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SWI6 as important for p85cdc10 function.

Authors:  A Reymond; S Schmidt; V Simanis
Journal:  Mol Gen Genet       Date:  1992-09

9.  The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats.

Authors:  C M Milner; R D Campbell
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

10.  Gene structure, regulatory control, and evolution of black widow venom latrotoxins.

Authors:  Kanaka Varun Bhere; Robert A Haney; Nadia A Ayoub; Jessica E Garb
Journal:  FEBS Lett       Date:  2014-09-12       Impact factor: 4.124
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