Literature DB >> 19775891

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

Jasmin Mecinović1, Christoph Loenarz, Rasheduzzaman Chowdhury, Christopher J Schofield.   

Abstract

Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.

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Year:  2009        PMID： 19775891     DOI： 10.1016/j.bmcl.2009.09.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Identification of novel potential HIF-prolyl hydroxylase inhibitors by in silico screening.

Authors:  Mahesh Kumar Teli; G K Rajanikant
Journal:  Mol Divers       Date:  2011-11-01       Impact factor: 2.943

2.  Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Authors:  Nathan R Rose; Esther C Y Woon; Anthony Tumber; Louise J Walport; Rasheduzzaman Chowdhury; Xuan Shirley Li; Oliver N F King; Clarisse Lejeune; Stanley S Ng; Tobias Krojer; Mun Chiang Chan; Anna M Rydzik; Richard J Hopkinson; Ka Hing Che; Michelle Daniel; Claire Strain-Damerell; Carina Gileadi; Grazyna Kochan; Ivanhoe K H Leung; James Dunford; Kar Kheng Yeoh; Peter J Ratcliffe; Nicola Burgess-Brown; Frank von Delft; Susanne Muller; Brian Marsden; Paul E Brennan; Michael A McDonough; Udo Oppermann; Robert J Klose; Christopher J Schofield; Akane Kawamura
Journal:  J Med Chem       Date:  2012-07-11       Impact factor: 7.446

Review 3.  Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases.

Authors:  Vaithinathan Selvaraju; Narasimham L Parinandi; Ram Sudheer Adluri; Joshua W Goldman; Naveed Hussain; Juan A Sanchez; Nilanjana Maulik
Journal:  Antioxid Redox Signal       Date:  2013-10-31       Impact factor: 8.401

4.  Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.

Authors:  Mark D Rosen; Hariharan Venkatesan; Hillary M Peltier; Scott D Bembenek; Kimon C Kanelakis; Lucy X Zhao; Barry E Leonard; Frances M Hocutt; Xiaodong Wu; Heather L Palomino; Theresa I Brondstetter; Peter V Haugh; Laurence Cagnon; Wen Yan; Lisa A Liotta; Andrew Young; Tara Mirzadegan; Nigel P Shankley; Terrance D Barrett; Michael H Rabinowitz
Journal:  ACS Med Chem Lett       Date:  2010-10-05       Impact factor: 4.345

Review 5.  Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

Authors:  Saravanan S Karuppagounder; Rajiv R Ratan
Journal:  J Cereb Blood Flow Metab       Date:  2012-03-14       Impact factor: 6.200

6.  Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.

Authors:  Maximiliano J Katz; Julieta M Acevedo; Christoph Loenarz; Diego Galagovsky; Phebee Liu-Yi; Marcelo Pérez-Pepe; Armin Thalhammer; Rok Sekirnik; Wei Ge; Mariana Melani; María G Thomas; Sergio Simonetta; Graciela L Boccaccio; Christopher J Schofield; Matthew E Cockman; Peter J Ratcliffe; Pablo Wappner
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

7.  Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Authors:  Ivanhoe K H Leung; Marina Demetriades; Adam P Hardy; Clarisse Lejeune; Tristan J Smart; Andrea Szöllössi; Akane Kawamura; Christopher J Schofield; Timothy D W Claridge
Journal:  J Med Chem       Date:  2013-01-04       Impact factor: 7.446

8.  A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.

Authors:  Rachel Schiller; Giuseppe Scozzafava; Anthony Tumber; James R Wickens; Jacob T Bush; Ganesha Rai; Clarisse Lejeune; Hwanho Choi; Tzu-Lan Yeh; Mun Chiang Chan; Bryan T Mott; James S O McCullagh; David J Maloney; Christopher J Schofield; Akane Kawamura
Journal:  ChemMedChem       Date:  2014-02-06       Impact factor: 3.466

9.  Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Authors:  Nathan R Rose; Esther C Y Woon; Guy L Kingham; Oliver N F King; Jasmin Mecinović; Ian J Clifton; Stanley S Ng; Jobina Talib-Hardy; Udo Oppermann; Michael A McDonough; Christopher J Schofield
Journal:  J Med Chem       Date:  2010-02-25       Impact factor: 7.446

10.  Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Authors:  Kar Kheng Yeoh; Mun Chiang Chan; Armin Thalhammer; Marina Demetriades; Rasheduzzaman Chowdhury; Ya-Min Tian; Ineke Stolze; Luke A McNeill; Myung Kyu Lee; Esther C Y Woon; Mukram M Mackeen; Akane Kawamura; Peter J Ratcliffe; Jasmin Mecinović; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2012-11-15       Impact factor: 3.876
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