Literature DB >> 19775092

Monoterpenoid indole alkaloids from Alstonia yunnanensis.

Tao Feng1, Yan Li, Xiang-Hai Cai, Xun Gong, Ya-Ping Liu, Rong-Ting Zhang, Xiang-Yun Zhang, Qin-Gang Tan, Xiao-Dong Luo.   

Abstract

Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC50 = 3.89 microM) and hepatocellular carcinoma SMMC-7721 (IC50 = 21.73 microM) cell lines.

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Year:  2009        PMID： 19775092     DOI： 10.1021/np900374s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Scope of the Reactions of Indolyl- and Pyrrolyl-Tethered N-Sulfonyl-1,2,3-triazoles: Rhodium(II)-Catalyzed Synthesis of Indole- and Pyrrole-Fused Polycyclic Compounds.

Authors:  Liangbing Fu; Huw M L Davies
Journal:  Org Lett       Date:  2017-03-30       Impact factor: 6.005

Review 2.  Sarpagine and Related Alkaloids.

Authors:  Ojas A Namjoshi; James M Cook
Journal:  Alkaloids Chem Biol       Date:  2015-10-09

3.  Indole Glycosides from Aqueous Fraction of Strychnos nitida.

Authors:  Bei Wang; Zhi Dai; Lu Liu; Xin Wei; Pei-Feng Zhu; Hao-Fei Yu; Ya-Ping Liu; Xiao-Dong Luo
Journal:  Nat Prod Bioprospect       Date:  2016-11-09

4.  Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.

Authors:  Yuan Li; Yunli Zhao; Xia Zhou; Wei Ni; Zhi Dai; Dong Yang; Junjun Hao; Lin Luo; Yaping Liu; Xiaodong Luo; Xudong Zhao
Journal:  Toxins (Basel)       Date:  2017-04-28       Impact factor: 4.546

5.  Assessment of Tissue Specific Distribution and Seasonal Variation of Alkaloids in Alstonia scholaris.

Authors:  Rohit Mahar; Nagarajan Manivel; Sanjeev Kanojiya; Dipak K Mishra; Sanjeev K Shukla
Journal:  Metabolites       Date:  2022-06-30

Review 6.  Indole alkaloids from marine sources as potential leads against infectious diseases.

Authors:  Paulo H B França; Daniel P Barbosa; Daniel L da Silva; Êurica A N Ribeiro; Antônio E G Santana; Bárbara V O Santos; José M Barbosa-Filho; Jullyana S S Quintans; Rosana S S Barreto; Lucindo J Quintans-Júnior; João X de Araújo-Júnior
Journal:  Biomed Res Int       Date:  2014-06-05       Impact factor: 3.411

7.  General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine.

Authors:  Rahul V Edwankar; Chitra R Edwankar; Jeffrey R Deschamps; James M Cook
Journal:  J Org Chem       Date:  2014-10-15       Impact factor: 4.354

8.  Monoterpenoid indole alkaloids from Alstonia yunnanensis and their cytotoxic and anti-inflammatory activities.

Authors:  Peng Cao; Yong Liang; Xu Gao; Xiao-Ming Li; Zhen-Quan Song; Guobiao Liang
Journal:  Molecules       Date:  2012-11-16       Impact factor: 4.411
  8 in total

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