INTRODUCTION: Epidemiological data suggests that 5-aminosalicylic acid (5-ASA), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood. METHODS AND RESULTS: Here we report that 5-ASA prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an S-phase and G2/M phase arrest, dependent on 5-ASA dosage and concentration, together with an increased mitotic index. In addition, prolonged cell cycle arrest by repeated 5-ASA treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death. CONCLUSION: These observations illustrate that 5-ASA has chemopreventive and chemotherapeutic properties.
INTRODUCTION: Epidemiological data suggests that 5-aminosalicylic acid (5-ASA), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood. METHODS AND RESULTS: Here we report that 5-ASA prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an S-phase and G2/M phase arrest, dependent on 5-ASA dosage and concentration, together with an increased mitotic index. In addition, prolonged cell cycle arrest by repeated 5-ASA treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death. CONCLUSION: These observations illustrate that 5-ASA has chemopreventive and chemotherapeutic properties.
Authors: Manisha Bajpai; Darren N Seril; James Van Gurp; Xin Geng; Janet Alvarez; Carlos D Minacapelli; Steve Gorin; Koushik K Das; Elizabeth Poplin; Jerry Cheng; Peter S Amenta; Kiron M Das Journal: Dig Dis Sci Date: 2018-11-26 Impact factor: 3.199
Authors: Anton Kuratnik; Virginia E Senapati; Rajeev Verma; Barbara G Mellone; Anthony T Vella; Charles Giardina Journal: Biochem Pharmacol Date: 2012-01-25 Impact factor: 5.858
Authors: Tom Julian Creed; Ann Caroline Williams; Steven William Dixon; Tracey Jane Collard; Eleanor May Harrisdotter Mortensson; Danny Nigel Legge; Adam Christian Chambers; Alexander Greenhough Journal: Br J Cancer Date: 2021-03-30 Impact factor: 9.075
Authors: Shaaban K Mohamed; Joel T Mague; Mehmet Akkurt; Hajjaj H M Abdu-Allah; Mustafa R Albayati Journal: Acta Crystallogr E Crystallogr Commun Date: 2015-04-09