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Literature DB >> 19774600

A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.

Ma Diarey B Tianero¹, Novriyandi Hanif, Nicole J de Voogd, Rob W M van Soest, Junichi Tanaka.

Abstract

A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.

Entities: Chemical Species

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Year: 2009 PMID： 19774600 DOI： 10.1002/cbdv.200800199

Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408

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Cited

5 in total

Review 1. Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

Authors: Eliana Alves; Marina Dias; Diana Lopes; Adelaide Almeida; Maria do Rosário Domingues; Felisa Rey
Journal: Antibiotics (Basel) Date: 2020-07-24

A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.

Review 1. Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.

2. New 2-methyl-13-icosenoic acid from the temperate calcisponge Leuconia johnstoni.

3. An acetylenic alkaloid from the calcareous sponge Leucetta sp.

4. A new polyunsaturated brominated fatty acid from a Haliclona sponge.

5. New records of the rare calcareous sponge Paragrantia waguensis Hôzawa, 1940.