Literature DB >> 19772837

An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis.

Can Zhang1, Aleister J Saunders.   

Abstract

The process of refolding or degrading misfolded proteins is the most important function of protein quality control (PQC) system. An imbalance between the capacity of PQC system and the quantity and severity of misfolded proteins may result in protein aggregate accumulation, which can ultimately contribute to a class of diseases referred to as conformational disorders. Numerous lines of evidence suggest that Ubiquilin 1 is an important component in PQC. Ubiquilin 1 has been indicated to be involved in the pathophysiology of neurodegenerative diseases and cancer. Here we review the evidence that Ubiquilin 1 is an important component of the PQC system and also review the role of Ubiquilin 1 in human diseases.

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Year:  2009        PMID： 19772837      PMCID： PMC3158983     

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  10 in total

Review 1.  Protein degradation and protection against misfolded or damaged proteins.

Authors:  Alfred L Goldberg
Journal:  Nature       Date:  2003-12-18       Impact factor: 49.962

Review 2.  Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.

Authors:  Rudolph E Tanzi; Lars Bertram
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

3.  Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.

Authors:  Lars Bertram; Matthew B McQueen; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
Journal:  Nat Genet       Date:  2007-01       Impact factor: 38.330

4.  Degradation-mediated protein quality control in the nucleus.

Authors:  Richard G Gardner; Zara W Nelson; Daniel E Gottschling
Journal:  Cell       Date:  2005-03-25       Impact factor: 41.582

5.  Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.

Authors:  Leann K Massey; Alex L Mah; Mervyn J Monteiro
Journal:  Biochem J       Date:  2005-11-01       Impact factor: 3.857

6.  Family-based association between Alzheimer's disease and variants in UBQLN1.

Authors:  Lars Bertram; Mikko Hiltunen; Michele Parkinson; Martin Ingelsson; Christoph Lange; Karunya Ramasamy; Kristina Mullin; Rashmi Menon; Andrew J Sampson; Monica Y Hsiao; Kathryn J Elliott; Gonül Velicelebi; Thomas Moscarillo; Bradley T Hyman; Steven L Wagner; K David Becker; Deborah Blacker; Rudolph E Tanzi
Journal:  N Engl J Med       Date:  2005-03-03       Impact factor: 91.245

Review 7.  Autophagy and neurodegeneration: when the cleaning crew goes on strike.

Authors:  Marta Martinez-Vicente; Ana Maria Cuervo
Journal:  Lancet Neurol       Date:  2007-04       Impact factor: 44.182

Review 8.  The roles of intracellular protein-degradation pathways in neurodegeneration.

Authors:  David C Rubinsztein
Journal:  Nature       Date:  2006-10-19       Impact factor: 49.962

9.  Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.

Authors:  A L Mah; G Perry; M A Smith; M J Monteiro
Journal:  J Cell Biol       Date:  2000-11-13       Impact factor: 10.539

10.  An AICD-based functional screen to identify APP metabolism regulators.

Authors:  Can Zhang; Preeti J Khandelwal; Ranjita Chakraborty; Trinna L Cuellar; Srikant Sarangi; Shyam A Patel; Christopher P Cosentino; Michael O'Connor; Jeremy C Lee; Rudolph E Tanzi; Aleister J Saunders
Journal:  Mol Neurodegener       Date:  2007-08-24       Impact factor: 14.195
  10 in total
  18 in total

1.  Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.

Authors:  Li Zeng; Bo Wang; Sean A Merillat; Eiko N Minakawa; Matthew D Perkins; Biswarathan Ramani; Sara J Tallaksen-Greene; Maria do Carmo Costa; Roger L Albin; Henry L Paulson
Journal:  Neurobiol Dis       Date:  2015-06-30       Impact factor: 5.996

2.  UBQLN1 interacts with SPEM1 and participates in spermiogenesis.

Authors:  Jianqiang Bao; Jie Zhang; Huili Zheng; Chen Xu; Wei Yan
Journal:  Mol Cell Endocrinol       Date:  2010-06-14       Impact factor: 4.102

3.  Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.

Authors:  Yanying Liu; Lanhai Lü; Casey L Hettinger; Gaofeng Dong; Dong Zhang; Khosrow Rezvani; Xuejun Wang; Hongmin Wang
Journal:  J Neurosci       Date:  2014-02-19       Impact factor: 6.167

4.  Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.

Authors:  Can Zhang; Andrew Browne; Daniel Child; Jason R Divito; Jesse A Stevenson; Rudolph E Tanzi
Journal:  J Biol Chem       Date:  2010-01-22       Impact factor: 5.157

Review 5.  Recent advances in the genetics of the ALS-FTLD complex.

Authors:  Huw R Morris; Adrian J Waite; Nigel M Williams; James W Neal; Derek J Blake
Journal:  Curr Neurol Neurosci Rep       Date:  2012-06       Impact factor: 5.081

Review 6.  Combating deleterious phase transitions in neurodegenerative disease.

Authors:  April L Darling; James Shorter
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2021-02-05       Impact factor: 4.739

7.  HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein.

Authors:  Jiyoung Kim; Jee-Hyun Yoon; Yeon-Soo Kim
Journal:  PLoS One       Date:  2013-11-29       Impact factor: 3.240

8.  A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.

Authors:  Douglas C Marchion; Elona Bicaku; Yin Xiong; Nadim Bou Zgheib; Entidhar Al Sawah; Xiaomang Ba Stickles; Patricia L Judson; Alex S Lopez; Christopher L Cubitt; Jesus Gonzalez-Bosquet; Robert M Wenham; Sachin M Apte; Anders Berglund; Johnathan M Lancaster
Journal:  Oncol Rep       Date:  2013-03-05       Impact factor: 3.906

9.  Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner.

Authors:  Maria Braoudaki; George I Lambrou; Konstantinos Vougas; Kalliopi Karamolegou; George T Tsangaris; Fotini Tzortzatou-Stathopoulou
Journal:  J Hematol Oncol       Date:  2013-07-12       Impact factor: 17.388

10.  Ubiquilin 2 is not associated with tau pathology.

Authors:  Anna Nölle; Elise S van Haastert; Rob Zwart; Jeroen J M Hoozemans; Wiep Scheper
Journal:  PLoS One       Date:  2013-09-26       Impact factor: 3.240
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