Literature DB >> 19772836

The busy life of regulatory T cells in systemic lupus erythematosus.

Antonio La Cava1.   

Abstract

CD4+CD25+Foxp3+ regulatory T (Treg) cells suppress the proliferation and release of cytokines in several subsets of immune cells. By doing so and by maintaining immune tolerance in peripheral tissues, Treg cells contribute to avert autoimmunity. Many studies have investigated how Treg cells operate in autoimmune diseases, and which cellular and molecular pathways are targeted by Treg cells. This review provides an update on the activities of Treg cells in systemic lupus erythematosus (SLE), an autoimmune disease characterized by the presence of hyperactive immune cells and aberrant antibody responses to multiple nuclear and cytoplasmic antigens.

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Year:  2009        PMID： 19772836

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  8 in total

1.  The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study.

Authors:  Antonella Afeltra; Antonietta Gigante; Domenico Paolo Emanuele Margiotta; Chiara Taffon; Rosario Cianci; Biagio Barbano; Marta Liberatori; Antonio Amoroso; Filippo Rossi Fanelli
Journal:  Intern Emerg Med       Date:  2015-02-27       Impact factor: 3.397

2.  Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy.

Authors:  Thomas Scambler; Conor Feeley; Michael F McDermott
Journal:  Ann Transl Med       Date:  2016-12

3.  Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia in a patient with systemic lupus erythematosus and lupus nephritis.

Authors:  Lütfi Akyol; Soner Önem; Metin Özgen; Mehmet Sayarlıoğlu
Journal:  Eur J Rheumatol       Date:  2015-06-24

4.  Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus.

Authors:  Samuel K Shimp; Cristen B Chafin; Nicole L Regna; Sarah E Hammond; Molly A Read; David L Caudell; Marissanichole Rylander; Christopher M Reilly
Journal:  Cell Mol Immunol       Date:  2012-04-30       Impact factor: 11.530

5.  Activity of childhood lupus nephritis is linked to altered T cell and cytokine homeostasis.

Authors:  Monika Edelbauer; Sudhir Kshirsagar; Magdalena Riedl; Heiko Billing; Burkhard Tönshoff; Dieter Haffner; Gerard Cortina; Oliver Amon; Sophia Ross; Jörg Dötsch; Gottfried Wechselberger; Lutz T Weber; Martin Dablander; Markus Anliker; Andrea Griesmacher; Elisabeth Steichen-Gersdorf
Journal:  J Clin Immunol       Date:  2012-01-08       Impact factor: 8.317

6.  Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.

Authors:  Eric S Sobel; Todd M Brusko; Ed J Butfiloski; Wei Hou; Shiwu Li; Carla M Cuda; Ariana N Abid; Westley H Reeves; Laurence Morel
Journal:  Arthritis Res Ther       Date:  2011-06-27       Impact factor: 5.156

7.  Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a Treg cell-deficient milieu.

Authors:  Nicholas A Young; Rahul Sharma; Alexandra K Friedman; Benjamin H Kaffenberger; Brad Bolon; Wael N Jarjour
Journal:  Arthritis Rheum       Date:  2013-12

8.  The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease.

Authors:  Ninghai Wang; Burcu Yigit; Cees E van der Poel; Marta Cuenca; Michael C Carroll; Roland W Herzog; Pablo Engel; Cox Terhorst
Journal:  Front Immunol       Date:  2019-04-17       Impact factor: 7.561
  8 in total

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