Literature DB >> 19772489

Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles.

Deepika Sharma1, Balasubramanian Narasimhan, Pradeep Kumar, Vikramjeet Judge, Rakesh Narang, Erik De Clercq, Jan Balzarini.   

Abstract

In the present study we have synthesized (4-nitrophenyl)-[2-(substituted phenyl)-benzoimidazol-1-yl]-methanones, (2-bromophenyl)-[2-(substituted phenyl)-benzoimidazol-1-yl]-methanone analogues (1-14) and evaluated them for their antimicrobial and antiviral potential. The results of antimicrobial screening indicated that none of the synthesized compounds were effective against the tested bacterial strains. Compounds 3, 11, 13 and compounds 5, 11, 12 were found to be active against Aspergillus niger and Candida albicans respectively, and may be further developed as antifungal agents. Furthermore, evaluation against a panel of different viruses pointed out the selective activity of compounds 5 and 6 against vaccinia virus and Coxsackie virus B4.

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Year:  2009        PMID： 19772489     DOI： 10.1080/14756360802694427

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  6 in total

1.  A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.

Authors:  Anke Burger-Kentischer; Doris Finkelmeier; Petra Keller; Jörg Bauer; Holger Eickhoff; Gerald Kleymann; Walid Abu Rayyan; Anurag Singh; Klaus Schröppel; Karin Lemuth; Karl-Heinz Wiesmüller; Steffen Rupp
Journal:  Antimicrob Agents Chemother       Date:  2011-07-11       Impact factor: 5.191

2.  Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use.

Authors:  Victor V Fedotov; Vladimir L Rusinov; Evgeny N Ulomsky; Evgeny M Mukhin; Evgeny B Gorbunov; Oleg N Chupakhin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-15       Impact factor: 1.490

3.  Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues.

Authors:  Sangeeta Narwal; Sanjiv Kumar; Prabhakar Kumar Verma
Journal:  Chem Cent J       Date:  2017-06-09       Impact factor: 4.215

4.  Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies.

Authors:  Alejandra Vázquez-Raygoza; Lucia Cano-González; Israel Velázquez-Martínez; Pedro Josué Trejo-Soto; Rafael Castillo; Alicia Hernández-Campos; Francisco Hernández-Luis; Jesús Oria-Hernández; Adriana Castillo-Villanueva; Claudia Avitia-Domínguez; Erick Sierra-Campos; Mónica Valdez-Solana; Alfredo Téllez-Valencia
Journal:  Molecules       Date:  2017-11-24       Impact factor: 4.411

5.  New Pyrazolo-Benzimidazole Mannich Bases with Antimicrobial and Antibiofilm Activities.

Authors:  Christina Zalaru; Florea Dumitrascu; Constantin Draghici; Isabela Tarcomnicu; Maria Marinescu; George Mihai Nitulescu; Rodica Tatia; Lucia Moldovan; Marcela Popa; Mariana Carmen Chifiriuc
Journal:  Antibiotics (Basel)       Date:  2022-08-12

6.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597
  6 in total

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