Kimberly Kenton1, Lior Lowenstein, Linda Brubaker. 1. Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola University Stritch School of Medicine, Maywood, Illinois, USA. kkenton@lumc.edu
Abstract
UNLABELLED: INTRODUCTION & HYPOTHESIS: Determine if treatment of urge incontinence with tolterodine results in changes in bladder and/or urethral sensation using Current Perception Threshold (CPT) testing. METHODS: Women with >or=1 incontinence episode on 7-day diary were treated with 4 mg of long-acting tolterodine for 2-months. At baseline and 2-months, participants had CPT testing of the urethral and bladder at 3 frequencies 2000, 250, and 5 Hz. Baseline and post-treatment measures were compared using Wilcoxon Signed Rank Test. RESULTS: Seventeen women underwent baseline CPT testing. Four discontinued medication due to side effects and did not have repeated testing. Urethral CPT at 250 Hz was lower after treatment (median 1.3 [Interquartile range .69-2.1] and .75 [.45-1.2], p = .003) and at 5 Hz trended toward a significant decrease (1.1 [1-1.9] and .84 [.32-1.1], p = .06). CONCLUSIONS: Urethral sensitivity improves after 2-months of tolterodine, suggesting it may restore urethral sensory nerves in addition to known motor effects. (c) 2009 Wiley-Liss, Inc.
UNLABELLED: INTRODUCTION & HYPOTHESIS: Determine if treatment of urge incontinence with tolterodine results in changes in bladder and/or urethral sensation using Current Perception Threshold (CPT) testing. METHODS:Women with >or=1 incontinence episode on 7-day diary were treated with 4 mg of long-acting tolterodine for 2-months. At baseline and 2-months, participants had CPT testing of the urethral and bladder at 3 frequencies 2000, 250, and 5 Hz. Baseline and post-treatment measures were compared using Wilcoxon Signed Rank Test. RESULTS: Seventeen women underwent baseline CPT testing. Four discontinued medication due to side effects and did not have repeated testing. Urethral CPT at 250 Hz was lower after treatment (median 1.3 [Interquartile range .69-2.1] and .75 [.45-1.2], p = .003) and at 5 Hz trended toward a significant decrease (1.1 [1-1.9] and .84 [.32-1.1], p = .06). CONCLUSIONS: Urethral sensitivity improves after 2-months of tolterodine, suggesting it may restore urethral sensory nerves in addition to known motor effects. (c) 2009 Wiley-Liss, Inc.
Authors: W Jerod Greer; Jonathan L Gleason; Kimberly Kenton; Jeff M Szychowski; Patricia S Goode; Holly E Richter Journal: Female Pelvic Med Reconstr Surg Date: 2015 Mar-Apr Impact factor: 2.091
Authors: Jonathan L Gleason; Kimberly Kenton; W Jerod Greer; Olga Ramm; Jeff M Szychowski; Tracey Wilson; Holly E Richter Journal: Neurourol Urodyn Date: 2012-11-20 Impact factor: 2.696
Authors: Stéphanie van der Lely; Melanie R Schmidhalter; Stephanie C Knüpfer; Andrea M Sartori; Marc P Schneider; Stephanie A Stalder; Thomas M Kessler; Martina D Liechti; Ulrich Mehnert Journal: BJU Int Date: 2021-10-28 Impact factor: 5.969