Literature DB >> 1977029

Antibody persistence in Gambian children after high-dose Edmonston-Zagreb measles vaccine.

H C Whittle1, H Campbell, S Rahman, J R Armstrong.   

Abstract

Measles antibody concentrations in Gambian children immunised at 4 months of age with a high-dose Edmonston-Zagreb (EZ) measles vaccine or at 9 months with conventional Schwarz vaccine were measured 5 months after vaccination, and at 18 and 36 months of age. Schwarz vaccinees produced, on average, a 2.4-fold higher concentration of measles haemagglutinin inhibiting (HAI) antibody than EZ vaccinees, but at 36 months of age 82 of 93 (88%) EZ vaccinees and 83 of 87 (95%) Schwarz vaccinees had measles plaque-neutralising antibody concentrations above the assumed protective level of 200 mIU/ml (p greater than 0.1). HAI antibody concentrations 5 months after vaccination were inversely related to the presence of maternal antibody at vaccination, but above protective levels; at 18 and 36 months of age there was no relation to antibody concentration at vaccination, and decay of HAI antibody between 18 and 36 months of age was similar for EZ and Schwarz vaccinees.

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Year:  1990        PMID： 1977029     DOI： 10.1016/0140-6736(90)92501-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  11 in total

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4.  Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial.

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5.  Evidence that measles virus hemagglutinin initiates modulation of leukocyte function-associated antigen 1 expression.

Authors:  A R Nagendra; C W Smith; P R Wyde
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

6.  Sex-specific differences in mortality after high-titre measles immunization in rural Senegal.

Authors:  P Aaby; B Samb; F Simondon; K Knudsen; A M Seck; J Bennett; L Markowitz; P Rhodes; H Whittle
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7.  Immunological impact of an additional early measles vaccine in Gambian children: responses to a boost at 3 years.

Authors:  Jainaba Njie-Jobe; Samuel Nyamweya; David J C Miles; Marianne van der Sande; Syed Zaman; Ebrima Touray; Safayet Hossin; Jane Adetifa; Melba Palmero; Sarah Burl; David Jeffries; Sarah Rowland-Jones; Katie Flanagan; Assan Jaye; Hilton Whittle
Journal:  Vaccine       Date:  2012-02-05       Impact factor: 3.641

8.  Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial.

Authors:  Cesário L Martins; May-Lill Garly; Carlito Balé; Amabelia Rodrigues; Henrik Ravn; Hilton C Whittle; Ida M Lisse; Peter Aaby
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Journal:  J Infect Dis       Date:  2016-01-27       Impact factor: 5.226

10.  Negative Correlation between Circulating CD4+FOXP3+CD127- Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria-Tetanus-Pertussis Vaccine Implies a Regulatory Role.

Authors:  Jorjoh Ndure; Fatou Noho-Konteh; Jane U Adetifa; Momodou Cox; Francis Barker; My Thanh Le; Lady C Sanyang; Adboulie Drammeh; Hilton C Whittle; Ed Clarke; Magdalena Plebanski; Sarah L Rowland-Jones; Katie L Flanagan
Journal:  Front Immunol       Date:  2017-08-14       Impact factor: 7.561
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