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Literature DB >> 19770280

Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii.

Vijaya Bharathi Srinivasan¹, Govindan Rajamohan, Wondwossen A Gebreyes.

Abstract

In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents, and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds.

Entities: Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19770280 PMCID： PMC2786332 DOI： 10.1128/AAC.00748-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

32 in total

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38 in total

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5. Functional Characterization of AbaQ, a Novel Efflux Pump Mediating Quinolone Resistance in Acinetobacter baumannii.

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6. Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors.

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Journal: Antimicrob Agents Chemother Date: 2014-08-11 Impact factor: 5.191

7. KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance.

Authors: Vijaya Bharathi Srinivasan; Govindan Rajamohan
Journal: Antimicrob Agents Chemother Date: 2013-07-08 Impact factor: 5.191