| Literature DB >> 19770068 |
Abhay Jere1, Mikako Fujita, Akio Adachi, Masako Nomaguchi.
Abstract
The Nef protein of primate lentiviruses (simian and human immunodeficiency viruses; SIV/HIVs) appears to be multi-functional and plays a pivotal role in viral persistence and pathogenesis in vivo. Of its numerous functions reported to date, the ability to enhance virion infectivity in indicator cell lines and to augment viral replication in peripheral blood mononuclear cells (PBMCs) and lymphocytes (PBLs) is very well conserved among various SIV/HIVs. This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function.Entities:
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Year: 2009 PMID： 19770068 DOI： 10.1016/j.micinf.2009.09.009
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700