J P W Burger1, E H Serne, F Nolte, Y M Smulders. 1. Department of Internal and Vascular Medicine, and the Institute for Cardiovascular Research (IcaR-VU), VU University Medical Center, Amsterdam, the Netherlands.
Abstract
OBJECTIVE: To test the hypothesis that in young, normotensive obese subjects, physical activity at a fixed, moderate workload, causes a more pronounced hypertensive effect than in lean subjects. PATIENTS AND METHODS: 24 subjects (12 with BMI >30 kg/m(2), 12 with BMI <25 kg/m(2)), underwent a moderate-intensity physical activity protocol (cycling at 100 W). Blood pressure and oxygen consumption were monitored continuously. RESULTS: In the obese subjects, physical activity caused a more pronounced increase in both systolic blood pressure (increase of 40.4 +/- 15.3 mmHg vs 21.2 +/- 10.2 mmHg in lean subjects; p=0.001) and diastolic blood pressure (17.5 +/- 17.9 mmHg vs 3.2 +/- 8.1 mmHg in lean subjects; p=0.02). In regression analyses, these differences were only partly explained by small differences in resting blood pressure. CONCLUSION: Healthy obese subjects show an enhanced prohypertensive response of both systolic and diastolic blood pressure to moderate-intensity physical activity.
OBJECTIVE: To test the hypothesis that in young, normotensive obese subjects, physical activity at a fixed, moderate workload, causes a more pronounced hypertensive effect than in lean subjects. PATIENTS AND METHODS: 24 subjects (12 with BMI >30 kg/m(2), 12 with BMI <25 kg/m(2)), underwent a moderate-intensity physical activity protocol (cycling at 100 W). Blood pressure and oxygen consumption were monitored continuously. RESULTS: In the obese subjects, physical activity caused a more pronounced increase in both systolic blood pressure (increase of 40.4 +/- 15.3 mmHg vs 21.2 +/- 10.2 mmHg in lean subjects; p=0.001) and diastolic blood pressure (17.5 +/- 17.9 mmHg vs 3.2 +/- 8.1 mmHg in lean subjects; p=0.02). In regression analyses, these differences were only partly explained by small differences in resting blood pressure. CONCLUSION: Healthy obese subjects show an enhanced prohypertensive response of both systolic and diastolic blood pressure to moderate-intensity physical activity.
Authors: Marco Canepa; Lars L Sorensen; Iraklis Pozios; Veronica L Dimaano; Hong-Chang Luo; Aurelio C Pinheiro; James B Strait; Claudio Brunelli; M Roselle Abraham; Luigi Ferrucci; Theodore P Abraham Journal: Am J Cardiol Date: 2013-10-15 Impact factor: 2.778