| Literature DB >> 1976760 |
G M Pasinetti1, D G Morgan, S A Johnson, S L Millar, C E Finch.
Abstract
Tyrosine hydroxylase (TH)-mRNA, assayed by in situ hybridization combined with TH immunocytochemistry, showed a selective increase in the ventral tegmental area (A-10) but not in the substantia nigra (A-9) midbrain dopaminergic (DAergic) neurons 3 days after reserpine treatment. TH-mRNA in locus ceruleus noradrenergic (A-4) neurons was increased by reserpine, as confirmed by RNA blot hybridization. These findings show that TH-mRNA is differentially regulated in midbrain DAergic neurons in response to reserpine.Entities:
Mesh：
Substances：
Year: 1990 PMID： 1976760 DOI： 10.1111/j.1471-4159.1990.tb04970.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372