| Literature DB >> 19766638 |
Rachel Young1, Bruno Passet, Marthe Vilotte, Edmond P Cribiu, Vincent Béringue, Fabienne Le Provost, Hubert Laude, Jean-Luc Vilotte.
Abstract
The prion protein PrP has a key role in transmissible spongiform encephalopathies but its biological function remains largely unknown. Recently, a related protein, Shadoo, was discovered. Its biological properties and brain distribution partially overlap that of PrP. We report that the Shadoo-encoding gene knockdown in PrP-knockout mouse embryos results in a lethal phenotype, occurring between E8 and E11, not observed on the wild-type genetic background. It reveals that these two proteins play a shared, crucial role in mammalian embryogenesis, explaining the lack of severe phenotype in PrP-knockout mammals, an appreciable step towards deciphering the biological role of this protein family.Entities:
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Year: 2009 PMID： 19766638 DOI： 10.1016/j.febslet.2009.09.027
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124