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Literature DB >> 19766558

Transposon silencing by piRNAs.

Abstract

In animal cells, small RNA molecules, called piRNAs, defend the genome against selfish DNA elements such as transposons. In this issue, Klattenhoff et al. (2009) report that an HP1 family protein, Rhino, is required for piRNA generation and transposon silencing in Drosophila germline cells. The results provide a link between heterochromatin and piRNA-mediated genome defense.

Entities: Chemical

Mesh：

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Year: 2009 PMID： 19766558 PMCID： PMC3244755 DOI： 10.1016/j.cell.2009.08.030

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

10 in total

1. Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Authors: Martin Zofall; Shiv I S Grewal
Journal: Mol Cell Date: 2006-06-09 Impact factor: 17.970

2. Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity.

Authors: A M Volpe; H Horowitz; C M Grafer; S M Jackson; C A Berg
Journal: Genetics Date: 2001-11 Impact factor: 4.562

3. A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.

Authors: Lalith S Gunawardane; Kuniaki Saito; Kazumichi M Nishida; Keita Miyoshi; Yoshinori Kawamura; Tomoko Nagami; Haruhiko Siomi; Mikiko C Siomi
Journal: Science Date: 2007-02-22 Impact factor: 47.728

4. Drosophila PIWI associates with chromatin and interacts directly with HP1a.

Authors: Brent Brower-Toland; Seth D Findley; Ling Jiang; Li Liu; Hang Yin; Monica Dus; Pei Zhou; Sarah C R Elgin; Haifan Lin
Journal: Genes Dev Date: 2007-09-15 Impact factor: 11.361

5. An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster.

Authors: Hang Yin; Haifan Lin
Journal: Nature Date: 2007-10-21 Impact factor: 49.962

6. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.

Authors: Carla Klattenhoff; Hualin Xi; Chengjian Li; Soohyun Lee; Jia Xu; Jaspreet S Khurana; Fan Zhang; Nadine Schultz; Birgit S Koppetsch; Anetta Nowosielska; Herve Seitz; Phillip D Zamore; Zhiping Weng; William E Theurkauf
Journal: Cell Date: 2009-09-03 Impact factor: 41.582

Review 7. Mighty Piwis defend the germline against genome intruders.

Authors: Kathryn A O'Donnell; Jef D Boeke
Journal: Cell Date: 2007-04-06 Impact factor: 41.582

8. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

Authors: Julius Brennecke; Alexei A Aravin; Alexander Stark; Monica Dus; Manolis Kellis; Ravi Sachidanandam; Gregory J Hannon
Journal: Cell Date: 2007-03-08 Impact factor: 41.582

9. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Authors: Mohammad R Motamedi; Eun-Jin Erica Hong; Xue Li; Scott Gerber; Carilee Denison; Steven Gygi; Danesh Moazed
Journal: Mol Cell Date: 2008-12-26 Impact factor: 17.970

10. Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila.

Authors: Danielle Vermaak; Steven Henikoff; Harmit S Malik
Journal: PLoS Genet Date: 2005-07-25 Impact factor: 5.917

10 in total

30 in total

9. Long interspersed nuclear elements (LINEs) show tissue-specific, mosaic genome and methylation-unrestricted, widespread expression of noncoding RNAs in somatic tissues of the rat.

Authors: Deepak K Singh; Pramod C Rath
Journal: RNA Biol Date: 2012-10-12 Impact factor: 4.652

Review 10. Biogenesis and Function of Transfer RNA-Related Fragments (tRFs).

Authors: Pankaj Kumar; Canan Kuscu; Anindya Dutta
Journal: Trends Biochem Sci Date: 2016-06-01 Impact factor: 13.807

Transposon silencing by piRNAs.

1. Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

2. Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity.

3. A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.

4. Drosophila PIWI associates with chromatin and interacts directly with HP1a.

5. An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster.

6. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.

Review 7. Mighty Piwis defend the germline against genome intruders.

8. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

9. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

10. Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila.

1. Transcriptome-wide analysis of small RNA expression in early zebrafish development.

2. Sequence-specific biosensors report drug-induced changes in epigenetic silencing in living cells.

Review 3. All's well that transcribes well: non-coding RNAs and post-stroke brain damage.

4. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila.

5. Genomic identification, rapid evolution, and expression of Argonaute genes in the tilapia, Oreochromis niloticus.

Review 6. Non-coding RNAs and neuroprotection after acute CNS injuries.

7. Altered expression of PIWI RNA in the rat brain after transient focal ischemia.

8. Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease.

9. Long interspersed nuclear elements (LINEs) show tissue-specific, mosaic genome and methylation-unrestricted, widespread expression of noncoding RNAs in somatic tissues of the rat.

Review 10. Biogenesis and Function of Transfer RNA-Related Fragments (tRFs).