| Literature DB >> 19766160 |
Shruti Shukla1, Archana Mehta, Pradeep Mehta, Suresh Prasad Vyas, Savita Shukla, Vivek K Bajpai.
Abstract
Caesalpinia bonducella FLEMING (Caesalpiniaceae) plant is well known for its medicinal and therapeutic values in Indian Ayurveda. However, to be clinically useful, more scientific data are needed. Therefore, in the present study, we investigated the effects of C. bonducella seed oil on acute and chronic inflammation. To assess the anti-inflammatory, antipyretic and analgesic activities, varied concentrations of the seed oil of C. bonducella (100, 200 and 400mg/kg orally) were tested in carrageenan-induced rat paw oedema, brewer's yeast-induced pyrexia, acetic acid-induced writhing and hot plate reaction time in experimental rats. The paw volumes, pyrexia and writhes in experimental rats were reduced significantly (p<0.05) as compared to that of control, and hot plate test showed significant licking effect in rats. These results clearly indicate that the oil of C. bonducella seeds could be a potential source for using as anti-inflammatory, antipyretic and analgesic agent. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19766160 DOI： 10.1016/j.fct.2009.09.015
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023