Literature DB >> 19765830

Immune response in lung cancer mouse model mimics human anti-Hu reactivity.

Meleeneh Kazarian1, Joaquim Calbo, Natalie Proost, Catherine L Carpenter, Anton Berns, Ite A Laird-Offringa.   

Abstract

Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice appear to show reactivity prior to clinical diagnosis of SCLC. This mouse model system will be useful to study SCLC-associated autoimmunity, its diagnostic value, and the potential protective role of oncoantigen-directed autoantibodies.

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Year:  2009        PMID： 19765830      PMCID： PMC2788043          DOI： 10.1016/j.jneuroim.2009.08.014

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  35 in total

1.  Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients.

Authors:  F Graus; F Keime-Guibert; R Reñe; B Benyahia; T Ribalta; C Ascaso; G Escaramis; J Y Delattre
Journal:  Brain       Date:  2001-06       Impact factor: 13.501

Review 2.  Paraneoplastic syndromes involving the nervous system.

Authors:  Robert B Darnell; Jerome B Posner
Journal:  N Engl J Med       Date:  2003-10-16       Impact factor: 91.245

Review 3.  Chemotherapy for small cell lung cancer.

Authors:  Alan B Sandler
Journal:  Semin Oncol       Date:  2003-02       Impact factor: 4.929

4.  Characterization of the interaction between neuronal RNA-binding protein HuD and AU-rich RNA.

Authors:  Sungmin Park-Lee; Soyoun Kim; Ite A Laird-Offringa
Journal:  J Biol Chem       Date:  2003-08-04       Impact factor: 5.157

5.  Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.

Authors:  R Meuwissen; S C Linn; M van der Valk; W J Mooi; A Berns
Journal:  Oncogene       Date:  2001-10-04       Impact factor: 9.867

6.  HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.

Authors:  S Park; D G Myszka; M Yu; S J Littler; I A Laird-Offringa
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

Review 7.  Therapeutic advances in small cell lung cancer.

Authors:  F P Worden; G P Kalemkerian
Journal:  Expert Opin Investig Drugs       Date:  2000-03       Impact factor: 6.206

8.  Low level anti-Hu reactivity: A risk marker for small cell lung cancer?

Authors:  Jeffrey A Tsou; Meleeneh Kazarian; Ankur Patel; Janice S Galler; Ite A Laird-Offringa; Catherine L Carpenter; Stephanie J London
Journal:  Cancer Detect Prev       Date:  2008-12-12

9.  Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy.

Authors:  Peter Sillevis Smitt; Joost Grefkens; Bertie de Leeuw; Martin van den Bent; Wim van Putten; Herbert Hooijkaas; Charles Vecht
Journal:  J Neurol       Date:  2002-06       Impact factor: 4.849

10.  Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.

Authors:  Ralph Meuwissen; Sabine C Linn; R Ilona Linnoila; John Zevenhoven; Wolter J Mooi; Anton Berns
Journal:  Cancer Cell       Date:  2003-09       Impact factor: 31.743
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  8 in total

Review 1.  Animal models of autoimmune neuropathy.

Authors:  Betty Soliven
Journal:  ILAR J       Date:  2014

2.  Radioligand-binding assay reveals distinct autoantibody preferences for type I interferons in APS I and myasthenia gravis subgroups.

Authors:  Liv Hapnes; Nick Willcox; Bergithe E V Oftedal; Jone F Owe; Nils Erik Gilhus; Anthony Meager; Eystein S Husebye; Anette S Bøe Wolff
Journal:  J Clin Immunol       Date:  2011-11-30       Impact factor: 8.317

Review 3.  Neuronal autoantigens--pathogenesis, associated disorders and antibody testing.

Authors:  Eric Lancaster; Josep Dalmau
Journal:  Nat Rev Neurol       Date:  2012-06-19       Impact factor: 42.937

4.  Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report.

Authors:  Katherina Bernadette Sreter; Blazenka Barisic; Marija Barisic Kutija; Suzana Kukulj; Miroslav Samarzija
Journal:  Mol Clin Oncol       Date:  2017-05-08

5.  Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.

Authors:  Mario A Pulido; Meleeneh Kazarian DerHartunian; Zhenxia Qin; Eric M Chung; Diane S Kang; Andrew W Woodham; Jeffrey A Tsou; Rinse Klooster; Omid Akbari; Lina Wang; W Martin Kast; Stephen V Liu; Jan J G M Verschuuren; Dana W Aswad; Ite A Laird-Offringa
Journal:  J Neuroimmunol       Date:  2016-09-03       Impact factor: 3.478

Review 6.  Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy.

Authors:  Meleeneh Kazarian; Ite A Laird-Offringa
Journal:  Mol Cancer       Date:  2011-03-30       Impact factor: 27.401

Review 7.  Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies: A beneficial antitumor immune response going awry.

Authors:  Béatrice Sl Pignolet; Christina Mt Gebauer; Roland S Liblau
Journal:  Oncoimmunology       Date:  2013-12-10       Impact factor: 8.110

8.  Prognostic value of the common tumour-infiltrating lymphocyte subtypes for patients with non-small cell lung cancer: A meta-analysis.

Authors:  Benchao Chen; Heng Li; Chao Liu; Xudong Xiang; Shuting Wang; Anhao Wu; Yan Shen; Gaofeng Li
Journal:  PLoS One       Date:  2020-11-10       Impact factor: 3.240
  8 in total

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