Literature DB >> 1976511

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

S Guazzi1, M Price, M De Felice, G Damante, M G Mattei, R Di Lauro.   

Abstract

The cDNA for TTF-1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned. The protein encoded by the cDNA shows binding properties indistinguishable from those of TTF-1 present in nuclear extracts of differentiated rat thyroid cells. The DNA binding domain of TTF-1 is a novel mammalian homeodomain that shows considerable sequence homology to the Drosophila NK-2 homeodomain. TTF-1 mRNA and corresponding binding activity are detected in thyroid and lung. The chromosomal localization of the TTF-1 gene has been determined in humans and mice and corresponds to chromosomes 14 and 12, respectively, demonstrating that the TTF-1 gene is not located within previously described clusters of homeobox-containing genes.

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Year:  1990        PMID： 1976511      PMCID： PMC552115          DOI： 10.1002/j.1460-2075.1990.tb07574.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  39 in total

1.  Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain.

Authors:  O Karlsson; S Thor; T Norberg; H Ohlsson; T Edlund
Journal:  Nature       Date:  1990-04-26       Impact factor: 49.962

2.  Chromosome assignment of the murine Hox-4.1 gene.

Authors:  D Pravtcheva; M Newman; L Hunihan; P Lonai; F H Ruddle
Journal:  Genomics       Date:  1989-10       Impact factor: 5.736

3.  DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome.

Authors:  M G Mattei; N Philip; E Passage; J P Moisan; J L Mandel; J F Mattei
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Culture of hormone-dependent functional epithelial cells from rat thyroids.

Authors:  F S Ambesi-Impiombato; L A Parks; H G Coon
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

5.  Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

Authors:  S Henikoff
Journal:  Gene       Date:  1984-06       Impact factor: 3.688

6.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus.

Authors:  G Colletta; A Pinto; P P Di Fiore; A Fusco; M Ferrentino; V E Avvedimento; N Tsuchida; G Vecchio
Journal:  Mol Cell Biol       Date:  1983-11       Impact factor: 4.272

8.  Inherited primary hypothyroidism in mice.

Authors:  W J Beamer; E M Eicher; L J Maltais; J L Southard
Journal:  Science       Date:  1981-04-03       Impact factor: 47.728

9.  A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter.

Authors:  D Civitareale; R Lonigro; A J Sinclair; R Di Lauro
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598

10.  Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster.

Authors:  S Schneuwly; A Kuroiwa; P Baumgartner; W J Gehring
Journal:  EMBO J       Date:  1986-04       Impact factor: 11.598
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  111 in total

1.  DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1.

Authors:  D J Steadman; D Giuffrida; E P Gelmann
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

2.  Expression and function of the homeodomain-containing protein Hex in thyroid cells.

Authors:  L Pellizzari; A D'Elia; A Rustighi; G Manfioletti; G Tell; G Damante
Journal:  Nucleic Acids Res       Date:  2000-07-01       Impact factor: 16.971

3.  Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: transgenic alterations and tertiary structure.

Authors:  Keita Koizumi; Carla Lintas; Marshall Nirenberg; Jin-Soo Maeng; Jeong-Ho Ju; James W Mack; James M Gruschus; Ward F Odenwald; James A Ferretti
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

4.  Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.

Authors:  M R Crompton; T J Bartlett; A D MacGregor; G Manfioletti; E Buratti; V Giancotti; G H Goodwin
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

5.  Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila.

Authors:  Lan-Hsiang Wang; Rebecca Chmelik; Marshall Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-13       Impact factor: 11.205

6.  Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

Authors:  M Zannini; H Francis-Lang; D Plachov; R Di Lauro
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

Review 7.  Lung organogenesis.

Authors:  David Warburton; Ahmed El-Hashash; Gianni Carraro; Caterina Tiozzo; Frederic Sala; Orquidea Rogers; Stijn De Langhe; Paul J Kemp; Daniela Riccardi; John Torday; Saverio Bellusci; Wei Shi; Sharon R Lubkin; Edwin Jesudason
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

8.  Hydrogen-deuterium exchange studies of the rat thyroid transcription factor 1 homeodomain.

Authors:  G Esposito; F Fogolari; G Damante; S Formisano; G Tell; A Leonardi; R Di Lauro; P Viglino
Journal:  J Biomol NMR       Date:  1997-06       Impact factor: 2.835

9.  Identification of homeobox genes expressed during the process of rat liver regeneration after partial hepatectomy.

Authors:  I Mizuta; N Ogasawara; H Yoshikawa; Y Sakoyama
Journal:  Biochem Genet       Date:  1996-02       Impact factor: 1.890

10.  Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways.

Authors:  Peng Hou; Ermal Bojdani; Mingzhao Xing
Journal:  J Clin Endocrinol Metab       Date:  2009-12-11       Impact factor: 5.958
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