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Literature DB >> 19764832

Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

Meihua Luo¹, Hongzhen He, Mark R Kelley, Millie M Georgiadis.

Abstract

Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.

Entities: Disease Gene Species

Mesh：

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Year: 2010 PMID： 19764832 PMCID： PMC2864659 DOI： 10.1089/ars.2009.2698

Source DB: PubMed Journal: Antioxid Redox Signal ISSN： 1523-0864 Impact factor: 8.401

202 in total

1. Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system.

Authors: Xiongbin Lu; Guillermina Lozano; Lawrence A Donehower
Journal: Mutat Res Date: 2003-01-28 Impact factor: 2.433

2. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

Authors: Sun Yang; Kaikobad Irani; Susan E Heffron; Frances Jurnak; Frank L Meyskens
Journal: Mol Cancer Ther Date: 2005-12 Impact factor: 6.261

Review 3. Chemopreventive activity of oltipraz.

Authors: M L Clapper
Journal: Pharmacol Ther Date: 1998-04 Impact factor: 12.310

4. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors: P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal: Nature Date: 1999-05-20 Impact factor: 49.962

Review 5. Mechanisms of human DNA repair: an update.

Authors: Markus Christmann; Maja T Tomicic; Wynand P Roos; Bernd Kaina
Journal: Toxicology Date: 2003-11-15 Impact factor: 4.221

Review 6. DNA damage and repair: from molecular mechanisms to health implications.

Authors: Fabio Altieri; Caterina Grillo; Manola Maceroni; Silvia Chichiarelli
Journal: Antioxid Redox Signal Date: 2008-05 Impact factor: 8.401

7. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.

Authors: Meihua Luo; Sarah Delaplane; Aihua Jiang; April Reed; Ying He; Melissa Fishel; Rodney L Nyland; Richard F Borch; Xiaoxi Qiao; Millie M Georgiadis; Mark R Kelley
Journal: Antioxid Redox Signal Date: 2008-11 Impact factor: 8.401

8. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease.

Authors: M M Georgiadis; M Luo; R K Gaur; S Delaplane; X Li; M R Kelley
Journal: Mutat Res Date: 2008-05-18 Impact factor: 2.433

9. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism.

Authors: Young R Seo; Mark R Kelley; Martin L Smith
Journal: Proc Natl Acad Sci U S A Date: 2002-09-30 Impact factor: 11.205

Review 10. Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

Authors: Kishor K Bhakat; Anil K Mantha; Sankar Mitra
Journal: Antioxid Redox Signal Date: 2009-03 Impact factor: 8.401

54 in total

1. Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.

Authors: Meihua Luo; Jun Zhang; Hongzhen He; Dian Su; Qiujia Chen; Michael L Gross; Mark R Kelley; Millie M Georgiadis
Journal: Biochemistry Date: 2012-01-04 Impact factor: 3.162

Review 2. APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.

Authors: Mark R Kelley; Millie M Georgiadis; Melissa L Fishel
Journal: Curr Mol Pharmacol Date: 2012-01 Impact factor: 3.339

3. Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme.

Authors: Dian Su; Sarah Delaplane; Meihua Luo; Don L Rempel; Bich Vu; Mark R Kelley; Michael L Gross; Millie M Georgiadis
Journal: Biochemistry Date: 2010-12-08 Impact factor: 3.162

4. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

Authors: Aditi Bapat; Lateca S Glass; Meihua Luo; Melissa L Fishel; Eric C Long; Millie M Georgiadis; Mark R Kelley
Journal: J Pharmacol Exp Ther Date: 2010-05-26 Impact factor: 4.030

5. MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage.

Authors: Sophia F Magkouta; Apostolos G Pappas; Photene C Vaitsi; Panagiotis C Agioutantis; Ioannis S Pateras; Charalampos A Moschos; Marianthi P Iliopoulou; Chrysavgi N Kosti; Heleni V Loutrari; Vassilis G Gorgoulis; Ioannis T Kalomenidis
Journal: JCI Insight Date: 2020-06-18

6. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.

Authors: Mark R Kelley; Meihua Luo; April Reed; Dian Su; Sarah Delaplane; Richard F Borch; Rodney L Nyland; Michael L Gross; Millie M Georgiadis
Journal: Antioxid Redox Signal Date: 2011-01-04 Impact factor: 8.401