Literature DB >> 1976451

Mitomycin C cross-resistance induced by adriamycin in human ovarian cancer cells in vitro.

K Mizuno1, Y Furuhashi, O Maeda, M Iwata, T Misawa, M Kawai, T Kano, Y Tomoda.   

Abstract

We prepared Adriamycin-resistant cancer cells by exposing an ovarian serous cystadenocarcinoma cell line to the drug. The resistant cells also showed cross-resistance to a wide variety of other compounds, including vincristine, vinblastine, actinomycin D, daunorubicin, mitomycin C and carboquone. Against vincristine, the cells showed a greater than 5,000-fold increase in resistance, far surpassing their resistance to the selection drug. The resistant cells displayed a decrease in intracellular Adriamycin content and an increase in the mRNA of the mdr-1 gene coding for P-glycoprotein, with no amplification of the DNA. In revertant cells, resistance to Adriamycin was lost, but that to mitomycin C was maintained. Adriamycin resistance was partially overcome by the addition of verapamil or cyclosporin A, but cross-resistance to mitomycin C was not influenced at all. These results strongly suggest that the resistance to mitomycin C observed in our Adriamycin-resistant cells was due to some other mechanism than that causing multidrug resistance.

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Year:  1990        PMID： 1976451     DOI： 10.1007/bf02897288

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  39 in total

1.  Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.

Authors:  K Dano
Journal:  Biochim Biophys Acta       Date:  1973-10-25

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Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

3.  Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

Authors:  J R Riordan; K Deuchars; N Kartner; N Alon; J Trent; V Ling
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

4.  Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

Authors:  M Inaba; H Kobayashi; Y Sakurai; R K Johnson
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

5.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors:  N Kartner; J R Riordan; V Ling
Journal:  Science       Date:  1983-09-23       Impact factor: 47.728

6.  Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil.

Authors:  G J Schuurhuis; H J Broxterman; J J van der Hoeven; H M Pinedo; J Lankelma
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

7.  An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

Authors:  K H Choi; C J Chen; M Kriegler; I B Roninson
Journal:  Cell       Date:  1988-05-20       Impact factor: 41.582

8.  Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

Authors:  D W Shen; A Fojo; J E Chin; I B Roninson; N Richert; I Pastan; M M Gottesman
Journal:  Science       Date:  1986-05-02       Impact factor: 47.728

9.  Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

Authors:  I B Roninson; J E Chin; K G Choi; P Gros; D E Housman; A Fojo; D W Shen; M M Gottesman; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

10.  Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

Authors:  T Tsuruo; H Iida; S Tsukagoshi; Y Sakurai
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701
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  6 in total

1.  Modulation of mitomycin C-induced multidrug resistance in vitro.

Authors:  R T Dorr; J D Liddil
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

2.  Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins.

Authors:  S Wakusawa; S Nakamura; K Miyamoto
Journal:  Jpn J Cancer Res       Date:  1997-01

3.  Distinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel.

Authors:  Stephen R Armstrong; Rashmi Narendrula; Baoqing Guo; Amadeo M Parissenti; Katherine L McCallum; Stephanie Cull; Carita Lannér
Journal:  J Ovarian Res       Date:  2012-11-30       Impact factor: 4.234

4.  Establishment and characterization of acquired resistance to platinum anticancer drugs in human ovarian carcinoma cells.

Authors:  T Misawa; F Kikkawa; O Maeda; N H Obata; K Higashide; N Suganuma; Y Tomoda
Journal:  Jpn J Cancer Res       Date:  1995-01

5.  Potentiation of cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) by amphotericin B in BALB/c nude mice bearing human ovarian carcinoma cells.

Authors:  M Kojima; F Kikkawa; H Oguchi; K Tamakoshi; O Maeda; N Suganuma; Y Tomoda
Journal:  Jpn J Cancer Res       Date:  1994-11

6.  Different effects of FK317 on multidrug-resistant tumor in vivo and in vitro.

Authors:  Y Naoe; M Inami; S Takagaki; S Matsumoto; I Kawamura; F Nishigaki; S Tsujimoto; T Manda; K Shimomura
Journal:  Jpn J Cancer Res       Date:  1998-10
  6 in total

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